Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha | MyBioSource MBS247657 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha

catalog :

MBS247657

quantity :

0.125 mL

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

P17-V

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS247657

products type :

Antibody

products full name :

Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha

products short name :

CD8A / CD8 Alpha

products name syn :

Anti-CD8A / CD8 Alpha Antibody (C-Terminus, clone P17-V) IHC-plus; CD8A; CD8a molecule; CD8a antigen; OKT8 T-cell antigen; Leu2 T-lymphocyte antigen; T8 T-cell antigen; T cell co-receptor; p32; CD8; Leu2; T-cell antigen Leu2; CD8 Alpha; Human CD8A; CD8 Alpha

other names :

T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a

products gene name :

CD8A

other gene names :

CD8A; CD8A; CD8; MAL; p32; Leu2; MAL

uniprot entry name :

CD8A_HUMAN

clonality :

Polyclonal

clone :

P17-V

host :

Rabbit

reactivity :

Human

sequence length :

235

specificity :

Human CD8

purity :

Purified

form :

20 mM Tris-HCl, pH 8.0, 20 mg/ml BSA, 0.05% sodium azide

concentration :

2.5 mg/ml

storage stability :

Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen)

app notes :

IHC-Fr (1:100 - 1:200), IHC-P (1:25 - 1:100). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Peptide derived from C-terminal region of human CD8.

other info2 :

Immunogen: CD8A / CD8 Alpha antibody was raised against peptide derived from C-terminal region of human CD8. Antigen Modification: C-Terminus

products description :

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain.

ncbi gi num :

22902134

ncbi acc num :

NP_001759.3

ncbi gb acc num :

NM_001768.6

uniprot acc num :

P01732

ncbi mol weight :

30,214 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386)

ncbi summary :

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

uniprot summary :

CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p12. Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; MHC class I protein binding; coreceptor activity; protein kinase binding. Biological Process: antigen processing and presentation; regulation of immune response; T cell activation; T cell mediated immunity; cytotoxic T cell differentiation; positive regulation of calcium-mediated signaling; immune response; defense response to virus; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Cd8 Deficiency, Familial

size1 :

0.125 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage