catalog number :
MBS247528
products full name :
Rabbit Polyclonal (IgG) to Human KRT17 / Cytokeratin 17
products short name :
KRT17 / Cytokeratin 17
products name syn :
Anti-KRT17 / Cytokeratin 17 Antibody (aa381-430) IHC-plus; KRT17; 39.1; Cytokeratin 17; Cytokeratin-17; K17; Keratin 17 epitope S2; Keratin 17 epitope S4; Keratin 17; PC2; PCHC1; CK-17; Keratin 17 epitope S1; Keratin-17; Human KRT17; Cytokeratin 17
other names :
keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 17; keratin, type I cytoskeletal 17; 39.1; CK-17; keratin-17; cytokeratin-17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4; keratin 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17
products gene name :
KRT17
other gene names :
KRT17; KRT17; PC; K17; PC2; PCHC1; CK-17; K17
uniprot entry name :
K1C17_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Keratin 17 Antibody detects endogenous levels of total Keratin 17 protein.
purity :
Immunoaffinity Purified
form :
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
storage stability :
Store at -20 degree C for up to one year.
tested application :
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human Keratin 17 (aa381-430).
other info2 :
Immunogen: KRT17 / Cytokeratin 17 antibody was raised against synthetic peptide from human Keratin 17 (aa381-430). Antigen Modification: aa381-430
products categories :
Family: Keratin
ncbi acc num :
NP_000413.1
ncbi gb acc num :
NM_000422.2
ncbi mol weight :
48,106 Da
ncbi pathways :
EGFR1 Signaling Pathway (198782); Glucocorticoid Receptor Regulatory Network Pathway (138014)
ncbi summary :
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
uniprot summary :
K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: cytoplasm; intermediate filament. Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding. Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth. Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2