Goat Polyclonal to Human PDGF-BB / PDGFB | MyBioSource MBS247170 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human PDGF-BB / PDGFB

catalog :

MBS247170

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS247170

products type :

Antibody

products full name :

Goat Polyclonal to Human PDGF-BB / PDGFB

products short name :

PDGF-BB / PDGFB

products name syn :

Anti-PDGF-BB / PDGFB Antibody (C-Terminus) IHC-plus; PDGFB; Becaplermin; PDGF-BB; PDGF-b; SSV; PDGF subunit B; PDGF-2; PDGF2; Proto-oncogene c-Sis; SIS; C-sis; PDGF; B chain; Human PDGF-BB; PDGFB

other names :

platelet-derived growth factor subunit B isoform 1 preproprotein; Platelet-derived growth factor subunit B; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor beta polypeptide; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN: Becaplermin

products gene name :

PDGF-BB

products gene name syn :

PDGFB

other gene names :

PDGFB; PDGFB; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; PDGF2; SIS; PDGF subunit B

uniprot entry name :

PDGFB_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Reactivity: Human, Bovine, Sheep. Predicted Reactivity: Monkey, Mouse, Rat, Bat, Dog, Horse.

sequence length :

241

specificity :

Human PDGFB.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (3.75 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration was determined to be 3.75ug/ml

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide KHRKFKHTHDKT from C-Terminus of human PDGFB (NP_002599.1; NP_148937.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Sheep, Bovine, Opossum (100%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Horse (92%). Epitope: aa222-233. Family/Subfamily: PDGF/not assigned-PDGF

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PDGF-BB / PDGFB antibody was raised against synthetic peptide KHRKFKHTHDKT from C-Terminus of human PDGFB (NP_002599.1; NP_148937.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Sheep, Bovine, Opossum (100%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Horse (92%); Cat (83%). Antigen Modification: C-Terminus

products categories :

Family: PDGF

products description :

PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

ncbi gi num :

4505681

ncbi acc num :

NP_002599.1

ncbi gb acc num :

NM_002608.2

uniprot acc num :

P01127

ncbi mol weight :

25,502 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Angiogenesis Pathway (198772); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764)

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

uniprot summary :

PDGFB: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Belongs to the PDGF/VEGF growth factor family. Protein type: Oncoprotein; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: Golgi membrane; extracellular space; cell surface; endoplasmic reticulum lumen; basolateral plasma membrane; cytoplasm; extracellular region. Molecular Function: collagen binding; identical protein binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; superoxide-generating NADPH oxidase activator activity; chemoattractant activity. Biological Process: extracellular matrix organization and biogenesis; positive regulation of cyclin-dependent protein kinase activity; nerve growth factor receptor signaling pathway; heart development; positive regulation of transcription, DNA-dependent; positive regulation of fibroblast growth factor receptor signaling pathway; cell projection biogenesis; protein amino acid phosphorylation; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; positive chemotaxis; transforming growth factor beta receptor signaling pathway; positive regulation of mitotic cell cycle, embryonic; cell growth; substrate-bound cell migration; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of chemotaxis; activation of protein kinase B; positive regulation of blood vessel endothelial cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase activity; blood vessel morphogenesis; positive regulation of endothelial cell proliferation; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis; embryonic placenta development; peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; platelet-derived growth factor receptor signaling pathway; positive regulation of smooth muscle cell migration; response to estradiol stimulus; response to insulin stimulus; platelet degranulation; positive regulation of MAPKKK cascade; positive regulation of glomerular filtration; positive regulation of cell proliferation; response to wounding; hemopoiesis; DNA replication; negative regulation of cell migration; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; peptidyl-serine phosphorylation; response to hypoxia; innate immune response; blood coagulation; positive regulation of DNA replication; positive regulation of cell migration. Disease: Meningioma, Familial, Susceptibility To; Dermatofibrosarcoma Protuberans; Basal Ganglia Calcification, Idiopathic, 5; Basal Ganglia Calcification, Idiopathic, 1

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage