Rabbit Polyclonal (IgG) to Human HNRNPL / hnRNP L | MyBioSource MBS247000 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human HNRNPL / hnRNP L

catalog :

MBS247000

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS247000

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human HNRNPL / hnRNP L

products short name :

HNRNPL / hnRNP L

products name syn :

Anti-HNRNPL / hnRNP L Antibody (aa61-110) IHC-plus; HNRNPL; HnRNP L; HnRNP-L; HNRPL; P/OKcl.14; Human HNRNPL; hnRNP L

other names :

heterogeneous nuclear ribonucleoprotein L isoform a; Heterogeneous nuclear ribonucleoprotein L; heterogeneous nuclear ribonucleoprotein L; hnRNP L; heterogeneous nuclear ribonucleoprotein L

products gene name :

HNRNPL

products gene name syn :

hnRNPL

other gene names :

HNRNPL; HNRNPL; HNRPL; hnRNP-L; P/OKcl.14; HNRPL; hnRNP L

uniprot entry name :

HNRPL_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

589

specificity :

hnRNP L Antibody detects endogenous levels of total hnRNP L protein.

purity :

Immunoaffinity Purified

form :

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

concentration :

1 mg/ml

storage stability :

Store at -20 degree C for up to one year.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human hnRNP L (aa61-110).

other info2 :

Immunogen: HNRNPL / hnRNP L antibody was raised against synthetic peptide from human hnRNP L (aa61-110). Antigen Modification: aa61-110

products description :

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L(HNRPL) is among the proteins that are stably associated with hnRNP complexes. HNRPL along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. HNRPL is present in the nucleoplasm as part of the HNRP complex.

ncbi gi num :

52632383

ncbi acc num :

NP_001524.2

ncbi gb acc num :

NM_001533.2

uniprot acc num :

P14866

ncbi mol weight :

50,561 Da

ncbi pathways :

Gene Expression Pathway (105937); Processing Of Capped Intron-Containing Pre-mRNA Pathway (160950); MRNA Splicing Pathway (105951); MRNA Splicing - Major Pathway (105952); MRNA Processing Pathway (198843)

ncbi summary :

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

hnRNP L: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA splicing; RNA-binding. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: nucleoplasm; membrane; cytoplasm; ribonucleoprotein complex; nucleus. Molecular Function: protein binding; RNA binding; nucleotide binding. Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage