antibody

Rabbit Polyclonal to Human CADPS

MBS246882

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human CADPS

CADPS

Anti-CADPS Antibody (N-Terminus) IHC-plus; CADPS; CAPS-1; CAPS1; CADPS1; KIAA1121; Human CADPS

calcium-dependent secretion activator 1 isoform 1; Calcium-dependent secretion activator 1; calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1; Ca++-dependent secretion activator; Calcium-dependent activator protein for secretion 1; CAPS-1

CADPS

CADPS; CADPS; CAPS; CAPS1; CADPS1; CAPS; CAPS1; KIAA1121; CAPS-1

CAPS1_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

1353

Immunoaffinity Purified

PBS, 0.02% sodium azide.

1 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (5 ug/ml), WB (0.25 - 0.5 ug/ml)

Target Species: Human. Immunogen Description: 21 amino acid peptide near the amino terminus of the human CAPS1.

Immunogen: CADPS antibody was raised against 21 amino acid peptide near the amino terminus of the human CAPS1. Antigen Modification: N-Terminus

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).

34452715

NP_003707.2

NM_003716.3

Q9ULU8

50,236 Da

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle. Chromosomal Location of Human Ortholog: 3p14.2. Cellular Component: cytoplasmic vesicle membrane; synapse; cell junction; cytosol. Molecular Function: protein binding; metal ion binding; protein kinase binding; lipid binding. Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming

0.05 mg

495 USD