Rabbit Polyclonal to Human NR6A1 / GCNF | MyBioSource MBS246731 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human NR6A1 / GCNF

catalog :

MBS246731

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS246731

products type :

Antibody

products full name :

Rabbit Polyclonal to Human NR6A1 / GCNF

products short name :

NR6A1 / GCNF

products name syn :

Anti-NR6A1 / GCNF Antibody (Ligand-binding Domain) IHC-plus; NR6A1; Germ cell nuclear factor; HGCNF; NR61; HRTR; RTR; Ncnf; GCNF; GCNF1; Human NR6A1; GCNF

other names :

nuclear receptor subfamily 6 group A member 1 isoform 1; Nuclear receptor subfamily 6 group A member 1; nuclear receptor subfamily 6 group A member 1; germ cell nuclear factor variant 1; retinoid receptor-related testis-specific receptor; retinoic acid receptor-related testis-associated receptor; nuclear receptor subfamily 6, group A, member 1; Germ cell nuclear factor; GCNF; hGCNF; Retinoid receptor-related testis-specific receptor; RTR; hRTR

products gene name :

NR6A1

products gene name syn :

GCNF

other gene names :

NR6A1; NR6A1; RTR; GCNF; NR61; hRTR; CT150; GCNF1; hGCNF; GCNF; GCNF; hGCNF; RTR; hRTR

uniprot entry name :

NR6A1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit

sequence length :

480

specificity :

Human NR6A1 / GCNF. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Upon arrival: Aliquot and store undilute at -20 degree C or below for up to 1 year. can be stored undilted at 4 degree C for up to 1 month. Aovid freeze thaw cycles.

tested application :

IHC - Paraffin

app notes :

IHC-P (10 ug/ml)

other info1 :

Target: NR6A1/GCNF. Target Species: Nuclear receptor subfamily 6, group A, member 1 (NR6A1). Immunogen Description: Synthetic 18 amino acid peptide from ligand-binding domain of human NR6A1 / GCNF. Family/Subfamily: NHR/ NR6 Germ cell nuclear factor-like). Immunogen Species: NR6A1/GCNF antibody was rasied agianst Human.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen Species: NR6A1/G. Immunogen: NR6A1 / GCNF antibody was raised against synthetic 18 amino acid peptide from ligand-binding domain of human NR6A1 / GCNF. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig (100%); Platypus (89%); Turkey, Chicken (83%). Epitope: Ligand-binding Domain

products categories :

Family: NHR. Subfamily: NR6 Germ cell nuclear factor-like

products description :

Germ cell nuclear factor (GCNF), a NR6 Germ Cell Nuclear Factor-Like Receptor, has been shown to affect gene expression in embryogenesis and spermatogenesis and is essential for embryonic survival and normal development. Loss of GCNF causes embryonic lethality and disrupts normal somitogenesis as well as neural-tube and axis formation. GCNF binds as a homodimer to the DR0 DNA response element and has been shown to regulate transcription of genes including protamines1 and 2 and Oct4. GCNF's repression function has been shown to be mediated by interaction with the co-repressors N-COR and SMRT in the absence of ligand. Three protein isoforms, GCNF-1, GCNF-2a, and GCNF-2b, have been documented in humans, and they are generated by differential usage of alternative splice acceptor sites of the fourth and seventh exons. GCNF-1, the longest isoform, has a distinct 5' UTR and contains 4 and 26 additional amino acids than the other two forms, respectively.

ncbi gi num :

53729325

ncbi acc num :

NP_201591.2

ncbi gb acc num :

NM_033334.3

uniprot acc num :

Q15406

ncbi mol weight :

53,908 Da

ncbi pathways :

Developmental Biology Pathway (477129); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway (1127697); Transcriptional Regulation Of Pluripotent Stem Cells Pathway (1127696)

ncbi summary :

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

uniprot summary :

NR6A1: Orphan nuclear receptor. Binds to a response element containing the sequence 5 -TCAAGGTCA-3 . May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the adult testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 9q33.3. Cellular Component: nucleoplasm; transcription factor complex. Molecular Function: ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity. Biological Process: cell proliferation; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; gamete generation; positive regulation of transcription from RNA polymerase II promoter; gene expression; spermatogenesis; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage