Mouse Monoclonal [clone 2G11] (IgG1,k) to Human SIPR3 / EDG3 / S1P3 | MyBioSource MBS246682 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 2G11] (IgG1,k) to Human SIPR3 / EDG3 / S1P3

catalog :

MBS246682

quantity :

0.05 mg

price :

555 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G11

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS246682

products type :

Antibody

products full name :

Mouse Monoclonal [clone 2G11] (IgG1,k) to Human SIPR3 / EDG3 / S1P3

products short name :

SIPR3 / EDG3 / S1P3

products name syn :

Anti-SIPR3 / EDG3 / S1P3 Antibody (clone 2G11) IHC-plus; S1PR3; EDG-3; EDG3; LPB3; S1P receptor EDG3; S1P3; S1P receptor Edg-3; S1P receptor 3; Human SIPR3; EDG3; S1P3

other names :

sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; G protein-coupled receptor, endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; sphingosine-1-phosphate receptor 3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3

products gene name :

SIPR3

products gene name syn :

EDG3; S1P3

other gene names :

S1PR3; S1PR3; EDG3; LPB3; S1P3; EDG-3; EDG3; S1P receptor 3; S1P3; S1P receptor Edg-3

uniprot entry name :

S1PR3_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

2G11

host :

Mouse

reactivity :

Human

sequence length :

378

specificity :

Human EDG3

purity :

Protein A Purified

form :

PBS, pH 7.4.

concentration :

0.36mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

IHC-Paraffin (10ug/ml), ELISA (Optimal dilution to be determined by the researcher.

other info1 :

Target Species: Human. Immunogen Description: Recombinant protein

other info2 :

Immunogen Type: SIPR3/ EDG3/ S1P3 anditbody was raised against recombinant protein.

products categories :

Family: GPCR. Subfamily: Lysophospholipid/Lysosphingolipid

products description :

EDG3, a Lysophospholipid/Lysosphingolipid Receptor, binds the vasoconstrictor sphingosine-1-phosphate and activates transcription of serum response element-driven reporter genes. EDG3 may regulate angiogenesis and vascular endothelial cell functions.

ncbi gi num :

38788193

ncbi acc num :

NP_005217.2

ncbi gb acc num :

NM_005226.3

uniprot acc num :

Q99500

ncbi mol weight :

42,250 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Lysosphingolipid And LPA Receptors Pathway (106376); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

uniprot summary :

S1PR3: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 9q22.1-q22.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; integrin binding; lipid binding. Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; elevation of cytosolic calcium ion concentration; regulation of interleukin-1 beta production; positive regulation of cell proliferation; cytokine production; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response

size1 :

0.05 mg

price1 :

555 USD

more info or order :

MyBioSource product webpage