Mouse Monoclonal [clone 1B7D7] (IgG1) to Human GPI | MyBioSource MBS246581 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 1B7D7] (IgG1) to Human GPI

catalog :

MBS246581

quantity :

0.05 mL

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B7D7

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS246581

products type :

Antibody

products full name :

Mouse Monoclonal [clone 1B7D7] (IgG1) to Human GPI

products short name :

GPI

products name syn :

Anti-GPI Antibody (clone 1B7D7) IHC-plus; GPI; AMF; Autocrine motility factor; Glucose phosphate isomerase; Hexose monophosphate isomerase; Hexosephosphate isomerase; Neuroleukin; Oxoisomerase; Phosphoglucose isomerase; Phosphohexomutase; Phosphohexose isomerase; SA36; PGI; SA-36; Human GPI

other names :

glucose-6-phosphate isomerase isoform 2; Glucose-6-phosphate isomerase; glucose-6-phosphate isomerase; neuroleukin; oxoisomerase; sperm antigen 36; sperm antigen-36; phosphohexomutase; phosphosaccharomutase; phosphohexose isomerase; phosphoglucose isomerase; autocrine motility factor; hexosephosphate isomerase; glucose phosphate isomerase; hexose monophosphate isomerase; glucose-6-phosphate isomerase; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36

products gene name :

GPI

other gene names :

GPI; GPI; AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; GPI; AMF; NLK; PGI; PHI; SA-36

uniprot entry name :

G6PI_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1B7D7

host :

Mouse

reactivity :

Human

sequence length :

558

specificity :

Human GPI

purity :

Ascites

form :

Ascites fluid, 0.03% sodium azide. Sourced in Ascites.

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:10000), IF (1:200 - 1:1000), IHC-P (1:200), WB (1:500 - 1:2000)

other info1 :

Target Species: Human. Immunogen Description: Purified recombinant fragment of human GPI expressed in E Coli.

other info2 :

Immunogen: GPI antibody was raised against purified recombinant fragment of human GPI expressed in E Coli.

ncbi gi num :

18201905

ncbi acc num :

NP_000166.2

ncbi gb acc num :

NM_000175.3

uniprot acc num :

P06744

ncbi mol weight :

64,325 Da

ncbi pathways :

Amino Sugar And Nucleotide Sugar Metabolism Pathway (82979); Amino Sugar And Nucleotide Sugar Metabolism Pathway (350); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Disease Pathway (530764); Gluconeogenesis Pathway (106204); Glucose Metabolism Pathway (106199); Glycogen Storage Diseases Pathway (1127581); Glycolysis Pathway (105911); Glycolysis (Embden-Meyerhof Pathway), Glucose = Pyruvate (413340)

ncbi summary :

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

uniprot summary :

G6PI: belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. A dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. Functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Protein type: EC 5.3.1.9; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - starch and sucrose; Apoptosis; Cytokine; Isomerase. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: nucleoplasm; extracellular space; neuron projection; membrane; cytoplasm; plasma membrane; cytosol. Molecular Function: monosaccharide binding; glucose-6-phosphate isomerase activity; growth factor activity; cytokine activity; intramolecular transferase activity. Biological Process: aldehyde catabolic process; methylglyoxal biosynthetic process; glycolysis; learning and/or memory; hemostasis; glucose 6-phosphate metabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; negative regulation of neuron apoptosis; angiogenesis; negative regulation of caspase activity; humoral immune response; gluconeogenesis. Disease: Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency

size1 :

0.05 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage