antibody

Mouse Monoclonal [clone S59-36] (IgG2b) to Rat GRIN2B / NMDAR2B / NR2B

MBS246120

0.05 mg

495 USD

monoclonal

mouse

nonconjugated

S59-36

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Mouse Monoclonal [clone S59-36] (IgG2b) to Rat GRIN2B / NMDAR2B / NR2B

GRIN2B / NMDAR2B / NR2B

Anti-GRIN2B / NMDAR2B / NR2B Antibody (aa20-271, clone S59-36) IHC-plus; GRIN2B; GluN2B; GluR epsilon 2; NMDA receptor 2B; NMDAR2B; NR2B; NR3; MRD6; HNR3; Rat GRIN2B; NMDAR2B; NR2B

glutamate receptor ionotropic, NMDA 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor ionotropic, NMDA 2B; NR3; glutamate receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3

GRIN2B

NMDAR2B; NR2B

GRIN2B; GRIN2B; MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B; NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3

NMDE2_HUMAN

Monoclonal

IgG2b

S59-36

Mouse

Human, Mouse, Rat

1484

Detects ~166 kD protein. No cross reactivity against NR2A.

Protein G Purified

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide

1 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP)

ICC (0.1 - 1 ug/ml), IHC-P (5 ug/ml), IP (1 - 10 ug/ml), WB (1 - 10 ug/ml)

Target: GRIN2B/NMDAR2B/NR2N. Target Species: Rat. Immunogen Description: Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B, accession number Q00960. Immunogen Species: GRIN2B/NMDAR2B/NR2B antibody was raised against Rat.

Immunogen: GRIN2B / NMDAR2B / NR2B antibody was raised against fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B, accession number Q00960. Antigen Modification: aa20-271. Antigen Type: Fusion protein. Immunogen: GRIN2B/ NMDAR2B/ NR2B antibody was raised against fusion protein amino acid 20-271 (extracellular N-terminus) of rat NR2B, accession number Q00960.

Family: Ion Channel. Subfamily: Glutamate receptor - ionotropic (NMDA receptor)

N-methyl-D-aspartate tNMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 sUbunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubropallidoluysian atrophy (DRPLA). Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged; memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.

167003331

NP_000825.2

NM_000834.3

Q13224

166,367 Da

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium. Chromosomal Location of Human Ortholog: 12p12. Cellular Component: postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; integral to plasma membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex. Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; calcium channel activity. Biological Process: synaptic transmission, glutamatergic; axon guidance; behavioral fear response; startle response; glutamate signaling pathway; in utero embryonic development; regulation of synaptic plasticity; learning; memory; synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; behavioral response to pain; sensory organ development; response to ethanol; learning and/or memory; suckling behavior; ionotropic glutamate receptor signaling pathway; transport; ephrin receptor signaling pathway; regulation of excitatory postsynaptic membrane potential. Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6

0.05 mg

495 USD