product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal [clone 61D3] (IgG1,k) to Human CD14
catalog :
MBS245943
quantity :
0.1 mg
price :
495 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
61D3
reactivity :
human
application :
immunohistochemistry, flow cytometry, FACS
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS245943
products type :
Antibody
products full name :
Mouse Monoclonal [clone 61D3] (IgG1,k) to Human CD14
products short name :
CD14
products name syn :
Anti-CD14 Antibody (clone 61D3) IHC-plus; CD14; CD14 molecule; CD14 antigen; Human CD14
other names :
monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; CD14 molecule; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14Cleaved into the following 2 chains:Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form
products gene name :
CD14
other gene names :
CD14; CD14
uniprot entry name :
CD14_HUMAN
clonality :
Monoclonal
isotype :
IgG1,k
clone :
61D3
host :
Mouse
reactivity :
Human
sequence length :
375
purity :
Affinity Purified
form :
PBS, pH 7.2, 150 mM sodium chloride, 0.09% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at 4 degree C, avoid repeated freeze thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS)
app notes :
Flo, IHC-P (20 ug/ml). Usage: The 61D3 antibody has been tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at less than or equal to 1 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final vol.
other info1 :
Target Species: Human. Immunogen Description: Human CD14
products description :
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells.
ncbi gi num :
4557417
ncbi acc num :
NP_000582.1
ncbi gb acc num :
NM_000591.3
uniprot acc num :
P08571
ncbi mol weight :
40,076 Da
ncbi pathways :
Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200)
ncbi summary :
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
uniprot summary :
CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; cell surface; extracellular region; plasma membrane; endosome membrane; lipid raft. Molecular Function: peptidoglycan receptor activity; protein binding; opsonin receptor activity; lipopolysaccharide binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; apoptosis; MyD88-independent toll-like receptor signaling pathway; positive regulation of endocytosis; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; phagocytosis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to magnesium ion; response to ethanol; cell surface receptor linked signal transduction; response to heat; toll-like receptor signaling pathway; innate immune response; response to electrical stimulus; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of cytokine secretion
size1 :
0.1 mg
price1 :
495 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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