Mouse Monoclonal (IgG1,k) to Human CCL20 / MIP-3-Alpha | MyBioSource MBS245814 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal (IgG1,k) to Human CCL20 / MIP-3-Alpha

catalog :

MBS245814

quantity :

0.5 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245814

products type :

Antibody

products full name :

Mouse Monoclonal (IgG1,k) to Human CCL20 / MIP-3-Alpha

products short name :

CCL20 / MIP-3-Alpha

products name syn :

Anti-CCL20 / MIP-3-Alpha Antibody IHC-plus; CCL20; Beta chemokine exodus-1; Beta-chemokine exodus-1; CKb4; Exodus-1; MIP-3a; MIP-3-alpha; LARC; ST38; SCYA20; C-C motif chemokine 20; CC chemokine LARC; Mip-3alpha; MIP3A; Small-inducible cytokine A20; Human CCL20; MIP-3-Alpha

other names :

C-C motif chemokine 20 isoform 1; C-C motif chemokine 20; C-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (C-C motif) ligand 20; Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20Cleaved into the following 3 chains:CCL20(1-67); CCL20(1-64); CCL20(2-70)

products gene name :

CCL20

other gene names :

CCL20; CCL20; CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha; LARC; MIP3A; SCYA20; MIP-3-alpha

uniprot entry name :

CCL20_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

host :

Mouse

reactivity :

Human

sequence length :

specificity :

Human MIP-3alpha

purity :

Protein A Purified

form :

Lyophilized from PBS. Sourced in TCS.

concentration :

1 mg/ml

storage stability :

Store Lyophilized at room temperature up to 1 month; Reconstituted for up to two weeks at 2-8 degree C. Aliquot and freeze at -20 degree C for long term storage. Avoid freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (2 - 4 ug/ml), IHC-P (10 ug/ml), WB (0.2 - 0.4 ug/ml). Usage: Immunohistochemistry: in an IHC-plus antibody, validated by our pathologists for use in IHC against formalin-fixed, paraffin-embedded human tissues (IHC validation procedure). A concentration of 10 ug/ml is recommended. ELISA: In a sandwich.

other info1 :

Target Species: Human. Resuspension Liquid Description: 500 ul sterile water. Immunogen Description: E.coli derived recombinant Human MIP-3alpha.

other info2 :

Immunogen Type: Cell extract. Immunogen: CCL20 / MIP-3-Alpha antibody was raised against e.coli derived recombinant Human MIP-3alpha.

products categories :

Family: Intercrine. Subfamily: Intercrine beta

products description :

Chemokines are a family of related proteins that regulate leukocyte migration (including into tissues) and activation in the face of inflammatory stimulus. CCL20/LARC/EXODUS/MIP-3 has been shown to be highly expressed in liver, and preferentially in lymphocytes and monocytes where its expression is upregulated by mediators of inflammation.

ncbi gi num :

4759076

ncbi acc num :

NP_004582.1

ncbi gb acc num :

NM_004591.2

uniprot acc num :

P78556

ncbi mol weight :

10,691 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); EBV LMP1 Signaling Pathway (198790); G Alpha (i) Signalling Events Pathway (119550)

ncbi summary :

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

uniprot summary :

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q36.3. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity. Biological Process: cell-cell signaling; wound healing; defense response to bacterium; immune response; inflammatory response; chemotaxis; signal transduction; positive regulation of interleukin-1 alpha biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process

size1 :

0.5 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage