Mouse Monoclonal [clone 1F2] (IgG1,k) to Human FGG / Fibrinogen Gamma | MyBioSource MBS245786 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 1F2] (IgG1,k) to Human FGG / Fibrinogen Gamma

catalog :

MBS245786

quantity :

0.05 mg

price :

555 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1F2

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245786

products type :

Antibody

products full name :

Mouse Monoclonal [clone 1F2] (IgG1,k) to Human FGG / Fibrinogen Gamma

products short name :

FGG / Fibrinogen Gamma

products name syn :

Anti-FGG / Fibrinogen Gamma Antibody (clone 1F2) IHC-plus; FGG; Fibrinogen gamma-b chain; Fibrinogen gamma chain; Fibrinogen; gamma polypeptide; Human FGG; Fibrinogen Gamma

other names :

fibrinogen gamma chain isoform gamma-B; Fibrinogen gamma chain; fibrinogen gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain

products gene name :

FGG

other gene names :

FGG; FGG

uniprot entry name :

FIBG_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

1F2

host :

Mouse

reactivity :

Human

sequence length :

453

specificity :

Human Fibrinogen Gamma-b Chain

purity :

Protein A Purified

form :

PBS, pH 7.4. Sourced in Ascites.

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000). Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell lysates and the recombinant protein used as the immunogen.

other info1 :

Target: FGG/Fibrinogen Gamma. Immunogen Species: FGG/Fibrinogen Gamma antibody was raised against Human. Target Species: Human. Immunogen Description: FGG (AAH07044, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

other info2 :

Immunogen: FGG / Fibrinogen Gamma antibody was raised against fGG (AAH07044, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

ncbi gi num :

70906439

ncbi acc num :

NP_068656.2

ncbi gb acc num :

NM_021870.2

uniprot acc num :

P02679

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Common Pathway (106060); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extracellular Matrix Organization Pathway (576262); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway (106055); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932)

ncbi summary :

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

FGG: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q28. Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region; plasma membrane; cell cortex; external side of plasma membrane. Molecular Function: protein binding, bridging; metal ion binding; cell adhesion molecule binding; structural molecule activity; receptor binding. Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; platelet degranulation; cellular protein complex assembly; positive regulation of protein secretion; cell-matrix adhesion; positive regulation of vasoconstriction; response to calcium ion; signal transduction; blood coagulation; positive regulation of exocytosis. Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital

size1 :

0.05 mg

price1 :

555 USD

more info or order :

MyBioSource product webpage