Mouse Monoclonal (IgG2a,k) to Human IL2RA / CD25 | MyBioSource MBS245666 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal (IgG2a,k) to Human IL2RA / CD25

catalog :

MBS245666

quantity :

0.5 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245666

products type :

Antibody

products full name :

Mouse Monoclonal (IgG2a,k) to Human IL2RA / CD25

products short name :

IL2RA / CD25

products name syn :

Anti-IL2RA / CD25 Antibody IHC-plus; IL2RA; CD25 antigen; CD25; IDDM10; IL-2 receptor subunit alpha; IL2R; Interleukin 2 receptor; alpha; IL-2-RA; IL2-RA; TCGFR; IL-2R subunit alpha; p55; TAC antigen; Human IL2RA; CD25

other names :

interleukin-2 receptor subunit alpha; Interleukin-2 receptor subunit alpha; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; interleukin 2 receptor, alpha; TAC antigen; p55; CD_antigen: CD25

products gene name :

IL2RA

products gene name syn :

CD25

other gene names :

IL2RA; IL2RA; p55; CD25; IL2R; TCGFR; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA

uniprot entry name :

IL2RA_HUMAN

clonality :

Monoclonal

isotype :

IgG2a,k

host :

Mouse

reactivity :

Human

sequence length :

272

specificity :

Human IL-2Ralpha

purity :

Protein G Purified

form :

Lyophilized from PBS

concentration :

1 mg/ml (After resuspension)

storage stability :

Store Lyophilized at room temperature up to 1 month; Reconstituted for up to two weeks at 2-8 degree C. Aliquot and freeze at -20 degree C for long term storage. Avoid freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-Fr (5 ug/ml), IHC-P (10 ug/ml), WB (0.2 - 0.4 ug/ml)

other info1 :

Target Species: Human. Target: IL2RA/CD25. Resuspension Liquid Description: Reconstitute in sterile water. Immunogen: IL2RA/CD25 antibody was raised against insect cell derived recombinant Human sIL-2Ralpha. Immunogen Species: IL2RA/CD25 antibody was raised against Human.

other info2 :

Antigen Type: Cell extract

products categories :

Family: Interleukin

products description :

Immunohistochemistry: MBS245666 in an IHC-plus antibody, validated by our pathologists for use in IHC against formalin-fixed, paraffin-embedded human tissues (IHC validation procedure). A concentration of 10 ug/ml is recommended. ELISA: In a sandwich ELISA (assuming 100 ul/well), a concentration of 4-8 ug/ml of this antibody will detect at least 100 pg/ml of recombinant Human sIL-2Ralpha when used in conjunction with compatible secondary reagents. Western Blot: To detect Human sIL-2Ralpha by Western Blot analysis this antibody can be used at a concentration of 0.20-0.40 ug/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant Human sIL-2Ralpha is 2-4 ng/lane, under non-reducing conditions.

ncbi gi num :

4557667

ncbi acc num :

NP_000408.1

ncbi gb acc num :

NM_000417.2

uniprot acc num :

P01589

ncbi pathways :

Arf6 Trafficking Events Pathway (137954); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Beta:gamma Signalling Through PI3Kgamma Pathway (119540)

ncbi summary :

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

uniprot summary :

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 10p15-p14. Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding. Biological Process: regulation of T cell homeostatic proliferation; Notch signaling pathway; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; cell surface receptor linked signal transduction; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis. Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10

size1 :

0.5 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage