Mouse Monoclonal [clone 8E3] (IgG2a,k) to Human PTPRN / IA-2 | MyBioSource MBS245594 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 8E3] (IgG2a,k) to Human PTPRN / IA-2

catalog :

MBS245594

quantity :

0.05 mg

price :

605 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[8E3]

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-PTPRN antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

image 2 :

Western blot of PTPRN expression in transfected 293T cell line by PTPRN monoclonal antibody, clone 8E3.

product information

catalog number :

MBS245594

products type :

Antibody

products full name :

Mouse Monoclonal [clone 8E3] (IgG2a,k) to Human PTPRN / IA-2

products short name :

[PTPRN / IA-2]

products name syn :

[Anti-PTPRN / IA-2 Antibody (clone 8E3) IHC-plus; PTPRN; ICA512; IA2; ICA 512; Islet antigen 2; Islet cell antigen 2; Islet cell autoantigen 3; IA-2; Ia-2 antigen; ICA3; PTP-NP-2; PTP IA-2; R-PTP-N; IA-2/PTP; Islet cell antigen 512; Human PTPRN; IA-2]

other names :

[receptor-type tyrosine-protein phosphatase-like N isoform 1; Receptor-type tyrosine-protein phosphatase-like N; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; protein tyrosine phosphatase, receptor type, N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2]

products gene name :

[PTPRN]

products gene name syn :

[IA-2]

other gene names :

[PTPRN; PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; ICA3; ICA512; R-PTP-N; ICA 512]

uniprot entry name :

PTPRN_HUMAN

clonality :

Monoclonal

isotype :

IgG2a,k

clone :

[8E3]

host :

Mouse

reactivity :

Human

sequence length :

979

specificity :

Human PTPRN

purity :

Protein A Purified

form :

PBS, pH 7.2

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml), WB. Usage: Western Blot: Transfected lysate, Recombinant protein.

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Western Blot (WB)

other info1 :

Target Species: Human. Immunogen Description: Recombinant protein

other info2 :

Immunogen Type: Recombinant protein

products categories :

Family: Protein Phosphatase. Subfamily: R8

products description :

PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

ncbi gi num :

4506321

ncbi acc num :

NP_002837.1

ncbi gb acc num :

NM_002846.3

uniprot acc num :

Q16849

ncbi mol weight :

96,261 Da

ncbi pathways :

Type I Diabetes Mellitus Pathway (83095); Type I Diabetes Mellitus Pathway (507)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

uniprot summary :

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor protein phosphatase, tyrosine; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q35-q36.1. Cellular Component: integral to membrane. Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity. Biological Process: response to reactive oxygen species; response to cAMP; insulin secretion; response to estrogen stimulus; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus

size1 :

0.05 mg

price1 :

605 USD

more info or order :

MyBioSource product webpage