antibody

Mouse Monoclonal [clone 5D6] (IgG1,k) to Human STAT5B / STAT

MBS245576

0.05 mg

555 USD

monoclonal

mouse

nonconjugated

5D6

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Mouse Monoclonal [clone 5D6] (IgG1,k) to Human STAT5B / STAT

STAT5B / STAT

Anti-STAT5B / STAT Antibody (clone 5D6) IHC-plus; STAT5B; Transcription factor STAT5B; STAT5; Human STAT5B; STAT

signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; transcription factor STAT5B; signal transducer and activator of transcription 5B

STAT5B

STAT

STAT5B; STAT5B; STAT5

STA5B_HUMAN

Monoclonal

IgG1,k

5D6

Mouse

Human

787

Human STAT5b

Protein A Purified

PBS, pH 7.4

0.45 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

ELISA, IF (25 ug/ml), IHC-P (5 ug/ml), WB. Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.

Target: STAT5B. Target Species: Human. Immunogen Description: STAT5B (NP_036580, 678 a.a. ~ 788 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen Species: STAT5B antibody was raised against Human. Antigen Type: Recombinant Protein

Immunogen: STAT5B / STAT antibody was raised against sTAT5B (NP_036580, 678 a.a. ~ 788 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

21618344

NP_036580.2

NM_012448.3

P51692

89,866 Da

AGE/RAGE Pathway (698754); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipogenesis Pathway (198832); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); BDNF Signaling Pathway (712093); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116)

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Protein type: Oncoprotein; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: protein dimerization activity; signal transducer activity; protein binding; double-stranded DNA binding; chromatin binding; protein phosphatase binding; transcription factor activity; glucocorticoid receptor binding. Biological Process: lactation; transcription from RNA polymerase II promoter; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; progesterone metabolic process; female pregnancy; positive regulation of multicellular organism growth; fatty acid metabolic process; positive regulation of mitotic cell cycle; positive regulation of activated T cell proliferation; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; luteinization; development of secondary male sexual characteristics; regulation of steroid metabolic process; creatinine metabolic process; acute-phase response; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer s patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; negative regulation of erythrocyte differentiation; citrate metabolic process; valine metabolic process; regulation of multicellular organism growth; development of secondary female sexual characteristics; positive regulation of cell motility; liver development; JAK-STAT cascade; positive regulation of natural killer cell mediated cytotoxicity; creatine metabolic process; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; response to hypoxia; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response; negative regulation of apoptosis. Disease: Growth Hormone Insensitivity With Immunodeficiency

0.05 mg

555 USD