product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal [clone 3E5] (IgG1,k) to Human VAMP2 / VAMP-2
catalog :
MBS245468
quantity :
0.05 mg
price :
495 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3.00E+05
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS245468
products type :
Antibody
products full name :
Mouse Monoclonal [clone 3E5] (IgG1,k) to Human VAMP2 / VAMP-2
products short name :
VAMP2 / VAMP-2
products name syn :
Anti-VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) IHC-plus; VAMP2; SYB2; Synaptobrevin 2; VAMP-2; Synaptobrevin-2; Human VAMP2; VAMP-2
other names :
vesicle-associated membrane protein 2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2); Synaptobrevin-2
products gene name :
VAMP2
products gene name syn :
VAMP-2
other gene names :
VAMP2; VAMP2; SYB2; VAMP-2; SYB2; VAMP-2
uniprot entry name :
VAMP2_HUMAN
clonality :
Monoclonal
isotype :
IgG1,k
clone :
3.00E+05
host :
Mouse
reactivity :
Human
sequence length :
116
purity :
Protein G Purified
form :
PBS, pH 7.4, 0.1% sodium azide. Sourced in Ascites.
concentration :
1 mg/ml
storage stability :
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA, IHC-P (10 ug/ml), WB (1:2000 - 1:3000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Recombinant human Synaptobrevin 2 (1-89aa) purified from E Coli.
other info2 :
Immunogen Type: Recombinant protein. Immunogen: VAMP2 / VAMP-2 antibody was raised against recombinant human Synaptobrevin 2 (1-89aa) purified from E Coli. Antigen Modification: aa1-89
products categories :
Family: Synaptobrevin
products description :
Synaptobrevin-2 is a small integral membrane protein specific for synaptic vesicles in neurons.
ncbi gi num :
172072620
ncbi acc num :
NP_055047.2
ncbi gb acc num :
NM_014232.2
uniprot acc num :
P63027
ncbi mol weight :
12,663 Da
ncbi pathways :
Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Clathrin Derived Vesicle Budding Pathway (119545); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Golgi Associated Vesicle Biogenesis Pathway (119546); Insulin Signaling Pathway (198845); Insulin Processing Pathway (105903)
ncbi summary :
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
uniprot summary :
VAMP2: a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Protein type: Vesicle; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: zymogen granule membrane; neuron projection; synaptic vesicle membrane; clathrin-coated vesicle; intracellular membrane-bound organelle; integral to plasma membrane; secretory granule membrane; trans-Golgi network; cytosol; secretory granule; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; cell junction. Molecular Function: calmodulin binding; SNAP receptor activity; SNARE binding; protein binding; protein self-association; syntaxin binding; syntaxin-1 binding; phospholipid binding; calcium-dependent protein binding. Biological Process: exocytosis; natural killer cell degranulation; neurotransmitter secretion; neutrophil degranulation; pathogenesis; calcium ion-dependent exocytosis; vesicle fusion; regulation of exocytosis; vesicle-mediated transport; synaptic transmission; synaptic vesicle exocytosis; protein transport; cellular protein metabolic process; cellular response to insulin stimulus; glutamate secretion; Golgi to plasma membrane protein transport; energy reserve metabolic process; response to glucose stimulus; eosinophil degranulation; protein complex assembly; post-Golgi vesicle-mediated transport; regulation of insulin secretion
size1 :
0.05 mg
price1 :
495 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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