product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal (IgG1) to Human ALPL / Alkaline Phosphatase
catalog :
MBS245455
quantity :
0.05 mg
price :
495 USD
clonality :
monoclonal
host :
mouse
conjugate :
AP
reactivity :
human, cow
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS245455
products type :
Antibody
products full name :
Mouse Monoclonal (IgG1) to Human ALPL / Alkaline Phosphatase
products short name :
ALPL / Alkaline Phosphatase
products name syn :
Anti-ALPL / Alkaline Phosphatase Antibody IHC-plus; ALPL; Alkaline phosphomonoesterase; AP-TNAP; Alkaline phosphatase liver; APTNAP; Glycerophosphatase; Tissue-nonspecific ALP; TNAP; HOPS; Liver alkaline phosphatase; TNSALP; Human ALPL; Alkaline Phosphatase
other names :
alkaline phosphatase, tissue-nonspecific isozyme isoform 1; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase, tissue-nonspecific isozyme; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme
products gene name :
ALPL
other gene names :
ALPL; ALPL; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; AP-TNAP; TNSALP
uniprot entry name :
PPBT_HUMAN
clonality :
Monoclonal
isotype :
IgG1
host :
Mouse
reactivity :
Bovine, Human
sequence length :
524
specificity :
Recognizes Alkaline Phosphatase from human bone. Species cross-reactivity: Alkaline phosphatase from human placenta and calf intestine.
purity :
Protein A Purified
form :
PBS, pH 7.2, 0.09% sodium azide
concentration :
1 mg/ml
storage stability :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA, IHC-P (10 ug/ml), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Purified alkaline phosphatase (native) from human bone.
other info2 :
Immunogen Type: Purified protein. Immunogen: ALPL / Alkaline Phosphatase antibody was raised against purified alkaline phosphatase (native) from human bone.
products description :
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.
ncbi gi num :
116734717
ncbi acc num :
NP_000469.3
ncbi gb acc num :
NM_000478.4
uniprot acc num :
P05186
ncbi mol weight :
51,045 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!BDNF Signaling Pathway 712093!!Endochondral Ossification Pathway 198812!!Folate Biosynthesis Pathway 83018!!Folate Biosynthesis Pathway 404!!Metabolic Pathways 132956!!TNF-alpha/NF-kB Signaling Pathway 198884
ncbi summary :
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
size :
0.05 mg
price :
495 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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