Mouse Monoclonal (IgG1,k) to Human MNSOD / SOD2 | MyBioSource MBS245407 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal (IgG1,k) to Human MNSOD / SOD2

catalog :

MBS245407

quantity :

0.05 mL

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS245407

products type :

Antibody

products full name :

Mouse Monoclonal (IgG1,k) to Human MNSOD / SOD2

products short name :

MNSOD / SOD2

products name syn :

Anti-MNSOD / SOD2 Antibody IHC-plus; SOD2; IPOB; MVCD6; Indophenoloxidase B; Mn superoxide dismutase; MNSOD; Mangano-superoxide dismutase; Human MNSOD; SOD2

other names :

superoxide dismutase; Superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase; superoxide dismutase 2, mitochondrial

products gene name :

MNSOD

products gene name syn :

SOD2

other gene names :

SOD2; SOD2; IPOB; MNSOD; MVCD6

uniprot entry name :

SODM_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

222

purity :

Purified

form :

HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

concentration :

1 mg/ml

storage stability :

Store at -20 degree C.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (1:50), WB (1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Recombinant human SOD2 purified from E Coli.

other info2 :

Immunogen Type: Recombinant protein. Immunogen: MNSOD / SOD2 antibody was raised against recombinant human SOD2 purified from E Coli.

ncbi gi num :

67782305

ncbi acc num :

NP_000627.2

ncbi gb acc num :

NM_000636.2

uniprot acc num :

P04179

ncbi mol weight :

19,730 Da

ncbi pathways :

Cellular Responses To Stress Pathway (645258); DNA Damage Response (only ATM Dependent) Pathway (198827); Detoxification Of Reactive Oxygen Species Pathway (1127552); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Oxidative Stress Pathway (198916); Peroxisome Pathway (131226); Peroxisome Pathway (131126)

ncbi summary :

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; Mitochondrial; EC 1.15.1.1. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane. Molecular Function: identical protein binding; DNA binding; manganese ion binding; superoxide dismutase activity; oxygen binding. Biological Process: oxygen homeostasis; positive regulation of nitric oxide biosynthetic process; removal of superoxide radicals; heart development; locomotory behavior; response to lipopolysaccharide; response to L-ascorbic acid; post-embryonic development; protein homotetramerization; negative regulation of cell proliferation; response to selenium ion; glutathione metabolic process; regulation of mitochondrial membrane potential; acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; regulation of catalytic activity; regulation of blood pressure; response to gamma radiation; hemopoiesis; negative regulation of neuron apoptosis; response to axon injury; response to electrical stimulus; response to drug; erythrophore differentiation; response to superoxide; release of cytochrome c from mitochondria; superoxide metabolic process; negative regulation of fat cell differentiation; liver development; regulation of transcription from RNA polymerase II promoter; response to manganese ion; response to silicon dioxide; response to reactive oxygen species; iron ion homeostasis; response to cadmium ion; response to hyperoxia; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; detection of oxygen; negative regulation of fibroblast proliferation; age-dependent response to reactive oxygen species; response to zinc ion; response to hypoxia; neuron development; response to activity; response to cold; induction of apoptosis by oxidative stress; superoxide release; hydrogen peroxide biosynthetic process. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6

size1 :

0.05 mL

price1 :

495 USD