catalog number :
MBS245403
products full name :
Mouse Monoclonal (IgG2a) to Human TG / Thyroglobulin
products short name :
TG / Thyroglobulin
products name syn :
Anti-TG / Thyroglobulin Antibody IHC-plus; TG; AITD3; TDH3; Thyroglobulin; TGN; Human TG; Thyroglobulin
other names :
thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin
other gene names :
TG; TG; TGN; AITD3; Tg
uniprot entry name :
THYG_HUMAN
reactivity :
Bovine, Human
specificity :
Specifically recognizes human thyroglobulin. Does not interfere with anti-thyroglobulin autoantibodies.
purity :
Protein G Purified
form :
PBS, pH 7.4, 0.1% sodium azide.
storage stability :
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
app notes :
ELISA, IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Thyroglobulin from human thyroid gland.
other info2 :
Immunogen Type: Purified protein. Immunogen: TG / Thyroglobulin antibody was raised against thyroglobulin from human thyroid gland.
products description :
Thyroglobulin (TG) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen.
ncbi acc num :
NP_003226.4
ncbi gb acc num :
NM_003235.4
ncbi mol weight :
298,383 Da
ncbi pathways :
Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Thyroxine (Thyroid Hormone) Production Pathway 920992
ncbi summary :
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]