Mouse Monoclonal [clone E11] (IgG1) to Human CR1 / CD35 | MyBioSource MBS245363 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone E11] (IgG1) to Human CR1 / CD35

catalog :

MBS245363

quantity :

0.05 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

E11

reactivity :

human, Rhesus monkey

application :

immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245363

products type :

Antibody

products full name :

Mouse Monoclonal [clone E11] (IgG1) to Human CR1 / CD35

products short name :

CR1 / CD35

products name syn :

Anti-CR1 / CD35 Antibody (clone E11, Azide-free) IHC-plus; CR1; C3b/C4b receptor; C3-binding protein; CD35; C3BR; Knops blood group antigen; C4BR; CD35 antigen; Complement receptor type 1; KN; Human CR1; CD35

other names :

complement receptor type 1 isoform S; Complement receptor type 1; complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component (3b/4b) receptor 1 (Knops blood group); C3b/C4b receptor; CD_antigen: CD35

products gene name :

CR1

products gene name syn :

CD35

other gene names :

CR1; CR1; KN; C3BR; C4BR; CD35; C3BR

uniprot entry name :

CR1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

E11

host :

Mouse

reactivity :

Cynomolgus monkey, Rhesus monkey, Baboon, Human

sequence length :

2489

specificity :

Is a single chain cell surface glycoprotein which exists in four allotypic forms (A, B, C, D) of 190kD, 220kD, 160kD and 250kD respectively. The molecule is expressed by granulocytes, monocytes, B cells and some T cells. Functionally CD35 acts as a receptor for the C3b component of complement. Clone E11 has been reported to be suitable for use in Western Blot.

purity :

Protein A Purified

form :

PBS, pH 7.4. Sourced in TCS.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Flow Cytometry (FC/FACS)

app notes :

Flo (1:50 - 1:100), IHC-Fr, IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Human acute monocytic leukaemia cells.

other info2 :

Immunogen Type: Cells. Immunogen: CR1 / CD35 antibody was raised against human acute monocytic leukaemia cells. Antibody Modification: Azide-free

products categories :

Family: Protease. Subfamily: Serine S1

ncbi gi num :

86793109

ncbi acc num :

NP_000642.3

ncbi gb acc num :

NM_000651.4

uniprot acc num :

P17927

ncbi mol weight :

223,663 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200); Legionellosis Pathway (469186)

ncbi summary :

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding. Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway. Disease: Knops Blood Group System; Malaria, Susceptibility To

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage