Mouse Monoclonal [clone 9E10] (IgG1) to Human MYC / c-Myc | MyBioSource MBS245318 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 9E10] (IgG1) to Human MYC / c-Myc

catalog :

MBS245318

quantity :

0.05 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9.00E+10

reactivity :

human, chimpanzee

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, FACS

product information

catalog number :

MBS245318

products type :

Antibody

products full name :

Mouse Monoclonal [clone 9E10] (IgG1) to Human MYC / c-Myc

products short name :

MYC / c-Myc

products name syn :

Anti-MYC / c-Myc Antibody (C-Terminus, clone 9E10) IHC-plus; MYC; BHLHe39; C-Myc; MRTL; Myc proto-oncogene protein; Proto-oncogene c-Myc; Rats1; Transcription factor p64; v-myc; Human MYC; c-Myc

other names :

myc proto-oncogene protein; Myc proto-oncogene protein; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc avian myelocytomatosis viral oncogene homolog; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

products gene name :

MYC

products gene name syn :

c-Myc

other gene names :

MYC; MYC; MRTL; MYCC; c-Myc; bHLHe39; BHLHE39; bHLHe39

uniprot entry name :

MYC_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

9.00E+10

host :

Mouse

reactivity :

Chimpanzee, Gorilla, Human. Predicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity)

sequence length :

454

specificity :

The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells

purity :

Protein G Purified

form :

PBS, 15 mM sodium azide, approx., pH 7.4.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

app notes :

Flo (1 - 5 ug/ml), IHC-P (10 ug/ml), IP (1 - 5 ug/ml), WB (0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan, Monkey, Marmoset, Tamarin (92%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MYC / c-Myc antibody was raised against synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan, Monkey, Marmoset, Tamarin (92%); Rat, Sheep, Hamster, Panda, Dog, Horse (85%). Antigen Modification: C-Terminus

ncbi gi num :

71774083

ncbi acc num :

NP_002458.2

ncbi gb acc num :

NM_002467.4

uniprot acc num :

P01106

ncbi mol weight :

50,565 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Apoptosis Pathway 198797!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!C-MYB Transcription Factor Network Pathway 138073!!C-MYC Pathway 169344!!CD40/CD40L Signaling Pathway 138061!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765

ncbi summary :

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

size :

0.05 mg

price :

495 USD