antibody

Mouse Monoclonal [clone SPM498] (IgG2a,k) to Human SLC2A1 / GLUT-1

MBS245316

0.25 mL

495 USD

monoclonal

mouse

nonconjugated

SPM498

human, rat

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Mouse Monoclonal [clone SPM498] (IgG2a,k) to Human SLC2A1 / GLUT-1

SLC2A1 / GLUT-1

Anti-SLC2A1 / GLUT-1 Antibody (C-Terminus, clone SPM498) IHC-plus; SLC2A1; EIG12; GLUT1DS; DYT17; DYT18; DYT9; Glucose transporter 1; HepG2 glucose transporter; Glucose transporter GLUT1; GLUT-1; GLUT1; PED; Human SLC2A1; GLUT-1

solute carrier family 2, facilitated glucose transporter member 1; Solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, facilitated glucose transporter member 1; hepG2 glucose transporter; receptor for HTLV-1 and HTLV-2; glucose transporter type 1, erythrocyte/brain; human T-cell leukemia virus (I and II) receptor; solute carrier family 2 (facilitated glucose transporter), member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter

SLC2A1

GLUT-1

SLC2A1; SLC2A1; PED; DYT9; GLUT; DYT17; DYT18; EIG12; GLUT1; HTLVR; GLUT-1; GLUT1DS; GLUT1; GLUT-1

GTR1_HUMAN

Monoclonal

IgG2a,k

SPM498

Mouse

Human, Rat

492

Protein G Purified

10 mM PBS, pH 7.4, BSA, sodium azide.

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC - Paraffin)

IHC-P (15 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide derived from C-terminal of human GLUT-1 protein.

Immunogen Type: Synthetic peptide. Immunogen: SLC2A1 / GLUT-1 antibody was raised against synthetic peptide derived from C-terminal of human GLUT-1 protein. Antigen Modification: C-Terminus

Family: Transporter. Subfamily: Sugar transporter

166795299

NP_006507.2

NM_006516.2

P11166

54,084 Da

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001)

This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]

GLUT1: an integral membrane protein that plays an important role in the glycolytic pathway by serving as a uniporter for glucose. One of 13 members of the human equilibrative glucose transport protein family. Transports a wide range of aldoses, including both pentoses and hexoses, and dehydroascorbic acid. Shown to transport water against an osmotic gradient. A receptor for the Human T-cell Leukemia virus (HTLV). Plays a role in the constitutive or basal uptake of glucose. Expressed at highest levels in proliferating cells of the early developing embryo, cells forming the blood tissue barriers, in human erythrocytes, astrocytes and in cardiac muscle. GLUT1 and GLUT3 are both essential for normal embryonic development. Is practically the only member of the GLUT family expressed on human red blood cells, where it comprises 10 - 20% of the integral membrane protein content. Several glycolytic proteins including the transporters GLUT1 and GLUT3, as well as multiple enzymes including HK2, PFKL, LDHA, ALDOA, ALDOC, PGK1, ENO1, PKM2, CA9 and PFKFB3 are induced in cancer cells by HIF-1 alpha. Polyps from Peutz-Jeghers patients exhibit up-regulated mTORC1 signaling, HIF-1alpha, and GLUT1 levels. Defects in GLUT1 are the cause of autosomal dominant GLUT1 deficiency syndrome, a blood-brain barrier glucose transport defect characterized by infantile seizures, delayed development, and acquired microcephaly. Defects also cause dystonia type 18, an exercise-induced paroxysmal dystonia/dyskinesia. Cytochalasin B binds to its inner surface, inhibiting its glucose transport activity with an IC50 of 0.44 uM. Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p34.2. Cellular Component: cortical actin cytoskeleton; membrane; basolateral plasma membrane; integral to plasma membrane; plasma membrane; melanosome; female pronucleus; intercellular junction; midbody; caveola; cytosol. Molecular Function: identical protein binding; D-glucose transmembrane transporter activity; xenobiotic transporter activity; protein binding; protein self-association; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; kinase binding. Biological Process: vitamin metabolic process; L-ascorbic acid metabolic process; pathogenesis; glucose transport; response to osmotic stress; cellular response to glucose starvation; hexose transport; carbohydrate metabolic process; energy reserve metabolic process; xenobiotic transport; protein complex assembly; transmembrane transport; regulation of insulin secretion; water-soluble vitamin metabolic process. Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 12; Dystonia 9; Glut1 Deficiency Syndrome 1; Glut1 Deficiency Syndrome 2

0.25 mL

495 USD