Mouse Monoclonal [clone 13B2AF] (IgG1,k) to Mouse GPX1 / Glutathione Peroxidase | MyBioSource MBS245296 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 13B2AF] (IgG1,k) to Mouse GPX1 / Glutathione Peroxidase

catalog :

MBS245296

quantity :

0.05 mL

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

HRP

clone name :

13B2AF

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245296

products type :

Antibody

products full name :

Mouse Monoclonal [clone 13B2AF] (IgG1,k) to Mouse GPX1 / Glutathione Peroxidase

products short name :

GPX1 / Glutathione Peroxidase

products name syn :

Anti-GPX1 / Glutathione Peroxidase Antibody (clone 13B2AF) IHC-plus; GPX1; Glutathione peroxidase; GSHPx-1; Glutathione peroxidase 1; GPx-1; GSHPX1; GPXD; Mouse GPX1; Glutathione Peroxidase

other names :

glutathione peroxidase 1 isoform 1; Glutathione peroxidase 1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; glutathione peroxidase 1; Cellular glutathione peroxidase

products gene name :

GPX1

other gene names :

GPX1; GPX1; GPXD; GSHPX1; GPx-1; GSHPx-1

uniprot entry name :

GPX1_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

13B2AF

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

203

purity :

Purified

form :

HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

app notes :

ELISA, IHC-P (1:50), IP, WB (1:5000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Mouse. Immunogen Description: Recombinant mouse protein purified from E Coli (Gpx1).

other info2 :

Immunogen Type: Recombinant protein. Immunogen: GPX1 / Glutathione Peroxidase antibody was raised against recombinant mouse protein purified from E Coli (Gpx1).

ncbi gi num :

41406084

ncbi acc num :

NP_000572.2

ncbi gb acc num :

NM_000581.2

uniprot acc num :

P07203

ncbi mol weight :

10,289 Da

ncbi pathways :

Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Direct P53 Effectors Pathway (137939); Folate Metabolism Pathway (198833)

ncbi summary :

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Protein type: EC 1.11.1.9; Oxidoreductase; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nucleus; cytosol. Molecular Function: selenium binding; glutathione binding; phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity; SH3 domain binding. Biological Process: fat cell differentiation; response to nicotine; blood vessel endothelial cell migration; response to toxin; myoblast proliferation; skeletal muscle fiber development; negative regulation of caspase activity; thermoregulation; regulation of gene expression, epigenetic; vasodilation; endothelial cell development; response to estradiol stimulus; regulation of mammary gland epithelial cell proliferation; response to selenium ion; sensory perception of sound; glutathione metabolic process; UV protection; response to symbiotic bacterium; lipoxygenase pathway; hydrogen peroxide catabolic process; response to folic acid; regulation of neuron apoptosis; response to glucose stimulus; arachidonic acid metabolic process; response to gamma radiation; negative regulation of inflammatory response to antigenic stimulus; aging; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; response to xenobiotic stimulus; positive regulation of protein kinase B signaling cascade; response to reactive oxygen species; triacylglycerol metabolic process; response to hydrogen peroxide; response to lipid hydroperoxide; cell redox homeostasis; heart contraction; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress. Disease: Glutathione Peroxidase Deficiency

size1 :

0.05 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage