Mouse Monoclonal [clone A53-B/A2.26] (IgG2a,l) to Human KRT19 / CK19 / Cytokeratin 19 | MyBioSource MBS245294 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone A53-B/A2.26] (IgG2a,l) to Human KRT19 / CK19 / Cytokeratin 19

catalog :

MBS245294

quantity :

0.125 mL

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A53-B/A2.26

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245294

products type :

Antibody

products full name :

Mouse Monoclonal [clone A53-B/A2.26] (IgG2a,l) to Human KRT19 / CK19 / Cytokeratin 19

products short name :

KRT19 / CK19 / Cytokeratin 19

products name syn :

Anti-KRT19 / CK19 / Cytokeratin 19 Antibody (aa312-335, clone A53-B/A2.26) IHC-plus; KRT19; CK19; Cytokeratin 19; Cytokeratin-19; Keratin 19; Keratin-19; CK-19; K19; K1CS; Keratin; type I; 40-kd; Human KRT19; CK19; Cytokeratin 19

other names :

keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 19; keratin, type I cytoskeletal 19; CK-19; keratin-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament; keratin 19; Cytokeratin-19; CK-19; Keratin-19; K19

products gene name :

KRT19

other gene names :

KRT19; KRT19; K19; CK19; K1CS; CK-19; K19

uniprot entry name :

K1C19_HUMAN

clonality :

Monoclonal

isotype :

IgG2a,l

clone :

A53-B/A2.26

host :

Mouse

reactivity :

Guinea pig, Human, Mouse, Rat

sequence length :

400

specificity :

Recognizes the rod domain of keratin 19 (40kD). Reacts with the MCF-7 cells, which are known to contain keratin 19. It shows no reaction with the cells lacking keratin 19 such as A431 and HeLa. Species cross-reactivity: Human. Weak reactivity with rat, mouse and guinea pig.

purity :

Protein G Purified

form :

10 mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.

concentration :

0.2 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Immunofluorescence (IF), Western Blot (WB)

app notes :

IF, IHC-Fr (1 - 2 ug/ml), IHC-P (10 ug/ml), WB (2 - 4 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Human breast cancer MCF-7 cells. Epitope: aa312-335 Cellular Localization: Cytoplasmic. MW of antigen: 40kD.

other info2 :

Immunogen: KRT19 / CK19 / Cytokeratin 19 antibody was raised against human breast cancer MCF-7 cells. Epitope: aa312-335 Cellular Localization: Cytoplasmic. MW of antigen: 40kD. Antigen Modification: aa312-335

products description :

Cytokeratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells.

ncbi gi num :

24234699

ncbi acc num :

NP_002267.2

ncbi gb acc num :

NM_002276.4

uniprot acc num :

P08727

ncbi mol weight :

44,106 Da

ncbi pathways :

Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

ncbi summary :

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

uniprot summary :

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma. Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle; protein complex binding. Biological Process: viral reproduction; response to estrogen stimulus; sarcomere organization

size1 :

0.125 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage