Mouse Monoclonal [clone 1H7] (IgG1) to Human IGF1R / IGF1 Receptor | MyBioSource MBS245289 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone 1H7] (IgG1) to Human IGF1R / IGF1 Receptor

catalog :

MBS245289

quantity :

0.05 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H7

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, FACS

product information

catalog number :

MBS245289

products type :

Antibody

products full name :

Mouse Monoclonal [clone 1H7] (IgG1) to Human IGF1R / IGF1 Receptor

products short name :

IGF1R / IGF1 Receptor

products name syn :

Anti-IGF1R / IGF1 Receptor Antibody (clone 1H7) IHC-plus; IGF1R; CD221 antigen; CD221; IGF1 Receptor; IGFR; IGF-I receptor; Soluble IGF1R variant 1; Soluble IGF1R variant 2; Type 1 IGF receptor; IGFIR; JTK13; Human IGF1R; IGF1 Receptor

other names :

insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain

products gene name :

IGF1R

other gene names :

IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor

uniprot entry name :

IGF1R_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1H7

host :

Mouse

reactivity :

Human

sequence length :

1367

specificity :

Recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221

purity :

Protein G Purified

form :

PBS, pH 7.4, 0.09% sodium azide.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)

app notes :

Flo (1:10), IHC-P (10 ug/ml), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human

products categories :

Family: Protein Kinase. Subfamily: Insulin receptor

products description :

IGF1R, an insulin receptor type protein kinase, mediates IGF1 stimulated cell proliferation and differentiation. IGF1R binds insulin-like growth factor I with high affinity and IGF II with a lower affinity. The protein has been shown to be highly expressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

ncbi gi num :

4557665

ncbi acc num :

NP_000866.1

ncbi gb acc num :

NM_000875.4

uniprot acc num :

P08069

ncbi mol weight :

154,793 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Apoptosis Pathway (198797); Endochondral Ossification Pathway (198812); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)

ncbi summary :

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

uniprot summary :

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; InsR family. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: neuron projection; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; caveola; receptor complex. Molecular Function: insulin binding; identical protein binding; insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; insulin receptor substrate binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; G-protein alpha-subunit binding; insulin receptor binding; ATP binding; insulin-like growth factor receptor activity. Biological Process: phosphoinositide 3-kinase cascade; epidermis development; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; response to vitamin E; mammary gland development; positive regulation of MAPKKK cascade; male sex determination; positive regulation of cell proliferation; protein tetramerization; positive regulation of cytokinesis; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; positive regulation of mitosis; negative regulation of transcription factor activity; positive regulation of protein kinase B signaling cascade; axonogenesis; insulin-like growth factor receptor signaling pathway; establishment of cell polarity; insulin receptor signaling pathway; immune response; brain development; positive regulation of DNA replication; positive regulation of cell migration; negative regulation of apoptosis. Disease: Insulin-like Growth Factor I, Resistance To

size1 :

0.05 mg

price1 :

495 USD