Mouse Monoclonal [clone AA1] (IgG1) to Human TPSAB1 / Mast Cell Tryptase | MyBioSource MBS245244 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal [clone AA1] (IgG1) to Human TPSAB1 / Mast Cell Tryptase

catalog :

MBS245244

quantity :

0.05 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AA1

reactivity :

human, rat, dog

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245244

products type :

Antibody

products full name :

Mouse Monoclonal [clone AA1] (IgG1) to Human TPSAB1 / Mast Cell Tryptase

products short name :

TPSAB1 / Mast Cell Tryptase

products name syn :

Anti-TPSAB1 / Mast Cell Tryptase Antibody (clone AA1) IHC-plus; TPSAB1; Alpha tryptase; Mast cell alpha II tryptase; Tryptase alpha-1; Tryptase beta I; Tryptase-III; TPSB1; Tryptase alpha II; TPS1; TPS2; Tryptase beta-1; Tryptase-1; Tryptase-I; Mast cell beta I tryptase; Tryptase alpha/beta 1; Human TPSAB1; Mast Cell Tryptase

other names :

tryptase alpha/beta-1; Tryptase alpha/beta-1; tryptase alpha/beta-1; tryptase I; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; mast cell beta I tryptase; mast cell alpha II tryptase; tryptase alpha/beta 1; Tryptase I; Tryptase alpha-1

products gene name :

TPSAB1

other gene names :

TPSAB1; TPSAB1; TPS1; TPS2; TPSB1; TPS1; TPS2; TPSB1; Tryptase-1

uniprot entry name :

TRYB1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

AA1

host :

Mouse

reactivity :

Cat, Dog, Human, Monkey, Rat

sequence length :

275

specificity :

Recognizes human mast cell tryptase, both alpha and beta isoforms. Is an excellent marker for mast cells, and does not bind to any other cell type in immunohistology.

purity :

Protein G Purified

form :

PBS, pH 7.4, 0.09% sodium azide.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-Fr, IHC-P (2.5 ug/ml), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Human mast cell tryptase purified from human lung tissue.

other info2 :

Immunogen Type: Purified protein. Immunogen: TPSAB1 / Mast Cell Tryptase antibody was raised against human mast cell tryptase purified from human lung tissue.

products categories :

Family: Protease. Subfamily: Serine S1

ncbi gi num :

13775595

ncbi acc num :

NP_003285.2

ncbi gb acc num :

NM_003294.3

uniprot acc num :

Q15661

ncbi mol weight :

29,533 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262)

ncbi summary :

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

uniprot summary :

TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; EC 3.4.21.59; Secreted; Protease. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage