This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal [clone 31A1067] (IgG) to Human CASP3 / Caspase 3
catalog :
MBS245207
quantity :
0.05 mg
price :
495 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
31A1067
reactivity :
human, mouse
application :
western blot, immunohistochemistry
product information
catalog number :
MBS245207
products type :
Antibody
products full name :
Mouse Monoclonal [clone 31A1067] (IgG) to Human CASP3 / Caspase 3
products short name :
CASP3 / Caspase 3
products name syn :
Anti-CASP3 / Caspase 3 Antibody (clone 31A1067) IHC-plus; CASP3; Apopain; CASP-3; Caspase-3; CPP32B; CPP32; Cysteine protease CPP32; SCA-1; SREBP cleavage activity 1; Yama; Procaspase3; Caspase 3; CPP-32; PARP cleavage protease; Protein Yama; Human CASP3; Caspase 3
other names :
caspase-3 preproprotein; Caspase-3; caspase-3; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; caspase 3, apoptosis-related cysteine peptidase; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
products gene name :
CASP3
other gene names :
CASP3; CASP3; CPP32; SCA-1; CPP32B; CPP32; CASP-3; CPP-32; SCA-1
uniprot entry name :
CASP3_HUMAN
clonality :
Monoclonal
isotype :
IgG
clone :
31A1067
host :
Mouse
reactivity :
Human, Mouse
sequence length :
277
specificity :
Full-length recombinant human caspase-3 protein was used as immunogen. The antibody recognizes an epitope in the large domain subunit of Caspase-3. As such it will recognize pro Caspase-3 and the large subunit cleavage fragment.
purity :
Protein G Purified
form :
PBS, 0.05% BSA, 0.05% sodium azide.
concentration :
0.5 mg/ml
storage stability :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
app notes :
IHC-P (5 ug/ml), WB (2 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Recombinant human CASP3 / Caspase 3.
other info2 :
Immunogen Type: Recombinant protein. Immunogen: CASP3 / Caspase 3 antibody was raised against recombinant human CASP3 / Caspase 3.
products categories :
Family: Protease. Subfamily: Cysteine C14
products description :
Caspase 3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase 3 proteolytically cleaves and activates other proteins. Caspase 3 has been associated with apoptosis.
ncbi gi num :
14790119
ncbi acc num :
NP_004337.2
ncbi gb acc num :
NM_004346.3
uniprot acc num :
P42574
ncbi mol weight :
31,608 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activation Of DNA Fragmentation Factor Pathway 105683!!Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway 105672!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975
ncbi summary :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
size :
0.05 mg
price :
495 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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