Mouse Monoclonal (IgG2a) to Human ADORA2A/Adenosine A2A Receptor | MyBioSource MBS245206 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal (IgG2a) to Human ADORA2A/Adenosine A2A Receptor

catalog :

MBS245206

quantity :

0.05 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS245206

products type :

Antibody

products full name :

Mouse Monoclonal (IgG2a) to Human ADORA2A/Adenosine A2A Receptor

products short name :

ADORA2A/Adenosine A2A Receptor

products name syn :

Anti-ADORA2A/Adenosine A2A Receptor Antibody (3rd Intracellular Domain) IHC-plus; Adenosine receptor A2a; ADORA2; A2a receptor; Adenosine A2a receptor; Adenosine A2 receptor; Adenosine receptor subtype A2a; HA2aR; RDC8; Human ADORA2A/Adenosine A2A Receptor

other names :

adenosine receptor A2a; Adenosine receptor A2a; adenosine receptor A2a; adenosine receptor subtype A2a; adenosine A2a receptor

products gene name :

ADORA2A

other gene names :

ADORA2A; ADORA2A; A2aR; RDC8; ADORA2; ADORA2

uniprot entry name :

AA2AR_HUMAN

clonality :

Monoclonal [7F6-G5-A2 / 7F6]

isotype :

IgG2a

host :

Mouse

reactivity :

Dog, Guinea pig, Human, Mouse, Rabbit, Rat

sequence length :

412

specificity :

Recognizes human adenosine receptor A2A at ~43kD.

purity :

Protein G Purified

form :

0.01M Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide

concentration :

0.5 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - 4% paraformaldehyde), Western Blot (WB), Flow Cytometry (FC/FACS)

app notes :

Flo, IHC-P (5 ug/ml), IHC-Pfa (1 ug/ml), WB (1:1000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: 6His-tagged full-length human recombinant A2A receptor. Epitope mapped to SQPLPGER in the third intracellular loop.

other info2 :

Immunogen Type: Recombinant protein. Immunogen: ADORA2A/Adenosine A2A Receptor antibody was raised against 6His-tagged full-length human recombinant A2A receptor. Epitope mapped to SQPLPGER in the third intracellular loop. Antigen Modification: 3rd Intracellular Domain

products categories :

Family: GPCR. Subfamily: Adenosine

products description :

The A2a Adenosine Receptor is a major target of caffeine. This receptor inhibits cell aggregation, induces vasodilation, and downregulates inflammation.

ncbi gi num :

5921992

ncbi acc num :

NP_000666.2

ncbi gb acc num :

NM_000675.5

uniprot acc num :

P29274

ncbi mol weight :

44,707 Da

ncbi pathways :

Activation Of TRKA Receptors Pathway (106456); Adenosine P1 Receptors Pathway (106375); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549)

ncbi summary :

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

uniprot summary :

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q11.23. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: identical protein binding; protein binding; enzyme binding; adenosine receptor activity, G-protein coupled. Biological Process: central nervous system development; nerve growth factor receptor signaling pathway; apoptosis; blood circulation; adenylate cyclase activation; phagocytosis; G-protein signaling, coupled to cAMP nucleotide second messenger; cell-cell signaling; sensory perception; cellular defense response; cAMP biosynthetic process; inflammatory response; blood coagulation; adenosine receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage