antibody

Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4

MBS245186

0.05 mg

495 USD

monoclonal

mouse

nonconjugated

76B357.1

human, mouse, rat

western blot, immunohistochemistry, flow cytometry, FACS

Antibody

Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4

TLR4

Anti-TLR4 Antibody (aa100-200, clone 76B357.1) IHC-plus; TLR4; CD284; CD284 antigen; Homolog of Drosophila toll; TLR-4; TOLL; ARMD10; Toll-like receptor 4; HToll; Human TLR4

toll-like receptor 4 isoform C; Toll-like receptor 4; toll-like receptor 4; hToll; homolog of Drosophila toll; toll-like receptor 4; hToll; CD_antigen: CD284

TLR4

TLR4; TLR4; TOLL; CD284; TLR-4; ARMD10

TLR4_HUMAN

Monoclonal

IgG2b,k

76B357.1

Mouse

Human, Mouse, Rat

799

A portion of amino acids 100-200 of human TLR4.

Protein G Purified

PBS, 0.05% BSA, 0.05% sodium azide.

0.5 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)

Flo, IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide from human TLR4.

Immunogen Type: Synthetic peptide. Immunogen: TLR4 antibody was raised against synthetic peptide from human TLR4. Antigen Modification: aa100-200

Family: Toll-like Receptor

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide.

4507533

NP_003257.1

NM_003266.3

O00206

73,301 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957!!HIF-1 Signaling Pathway 695200!!Hepatitis B Pathway 694606!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

0.05 mg

495 USD