Mouse Monoclonal (IgG2b) to Human MME / CD10 | MyBioSource MBS245033 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Monoclonal (IgG2b) to Human MME / CD10

catalog :

MBS245033

quantity :

0.05 ml

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS245033

products type :

Antibody

products full name :

Mouse Monoclonal (IgG2b) to Human MME / CD10

products short name :

MME / CD10

products name syn :

Anti-MME / CD10 Antibody IHC-plus; MME; Atriopeptidase; CALLA; CD10; EPN; Membrane metallo-endopeptidase; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11; CD10 antigen; Enkephalinase; Neprylisin; SFE; Skin fibroblast elastase; Human MME; CD10

other names :

neprilysin; Neprilysin; neprilysin; enkephalinase; atriopeptidase; neprilysin-390; neprilysin-411; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10

products gene name :

MME

products gene name syn :

CD10

other gene names :

MME; MME; NEP; SFE; CD10; CALLA; EPN; CALLA; NEP; Neutral endopeptidase; SFE

uniprot entry name :

NEP_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

host :

Mouse

reactivity :

Human

sequence length :

750

specificity :

Ni-NTA purified recombinant human CD-10 expressed in E Coli strain BL21 (DE3)

purity :

Protein G Purified

form :

PBS, pH 7.4, 0.03% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), ELISA (EIA)

app notes :

ELISA (1:10000), IHC-Fr (1:200 - 1:400), IHC-P (1:100 - 1:200). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Recombinant human MME / CD10.

other info2 :

Immunogen Type: Recombinant protein. Immunogen: MME / CD10 antibody was raised against recombinant human MME / CD10.

products categories :

Family: Protease. Subfamily: Metallopeptidase M13

products description :

MME, also known as Neprilysin or CALLA for common acute lymphocytic leukemia antigen, is a Metallopeptidase M13 type protease. MME functions as a peptidase and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. The protein is found on leukemic cells of pre-B phenotype and serves as a cell-surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).

ncbi gi num :

116256329

ncbi acc num :

NP_000893.2

ncbi gb acc num :

NM_000902.3

uniprot acc num :

P08473

ncbi mol weight :

85,514 Da

ncbi pathways :

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Metabolism Of Angiotensinogen To Angiotensins Pathway 685555!!Metabolism Of Proteins Pathway 106230!!Peptide Hormone Metabolism Pathway 771603!!Protein Digestion And Absorption Pathway 172847!!Protein Digestion And Absorption Pathway 171868

ncbi summary :

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

size :

0.05 ml

price :

495 USD