product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal [clone R10/99] (IgG1) to Human IAPP / Amylin
catalog :
MBS245007
quantity :
0.05 mL
price :
495 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
R10/99
reactivity :
human
application :
immunohistochemistry, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS245007
products type :
Antibody
products full name :
Mouse Monoclonal [clone R10/99] (IgG1) to Human IAPP / Amylin
products short name :
IAPP / Amylin
products name syn :
Anti-IAPP / Amylin Antibody (clone R10/99) IHC-plus; IAPP; Diabetes-associated peptide; Islet amyloid polypeptide; AMYLIN; IAP; Insulinoma amyloid peptide; Human IAPP; Amylin
other names :
islet amyloid polypeptide; Islet amyloid polypeptide; islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
products gene name :
IAPP
other gene names :
IAPP; IAPP; DAP; IAP; DAP
uniprot entry name :
IAPP_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
R10/99
host :
Mouse
reactivity :
Human
sequence length :
89
purity :
Tissue culture supernatant
form :
Tissue culture supernatant, 0.09% sodium azide. Sourced in TCS.
storage stability :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin, IHC - Frozen), Immunofluorescence (IF)
app notes :
IF, IHC-Fr, IHC-P (1:100). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.
other info1 :
Target Species: Human. Immunogen Description: CATQRLANFLV coupled to tuberculin.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: IAPP / Amylin antibody was raised against cATQRLANFLV coupled to tuberculin.
products description :
Islet of insulinoma amyloid polypeptide (IAPP) is a 37 amino acids monomeric polypeptide isolated from pancreatic amyloid. It is commonly found in the islet of patients with diabetes mellitus type II and in insulinomas. IAPP selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
ncbi gi num :
4557655
ncbi acc num :
NP_000406.1
ncbi gb acc num :
NM_000415.2
uniprot acc num :
P10997
ncbi mol weight :
9,806 Da
ncbi pathways :
Amyloids Pathway (366238); Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Developmental Biology Pathway (477129); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Integrated Pancreatic Cancer Pathway (711360)
ncbi summary :
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
uniprot summary :
IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p12.1. Cellular Component: extracellular space; cell soma; extracellular region. Molecular Function: identical protein binding; hormone activity; receptor binding. Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; negative regulation of bone resorption; sensory perception of pain; signal transduction; endocrine pancreas development
size1 :
0.05 mL
price1 :
495 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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