Rabbit Polyclonal (IgG) to Human GPR44 / CRTH2 | MyBioSource MBS244950 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human GPR44 / CRTH2

catalog :

MBS244950

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS244950

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human GPR44 / CRTH2

products short name :

GPR44 / CRTH2

products name syn :

Anti-GPR44 / CRTH2 Antibody (aa329-348) IHC-plus; PTGDR2; CD294; CRTH2; CD294 antigen; DP2; DL1R; G protein-coupled receptor 44; G-protein coupled receptor 44; HCRTH2; DP2 prostaglandin receptor; GPR44; Prostaglandin D2 receptor 2; Human GPR44; CRTH2

other names :

prostaglandin D2 receptor 2; Prostaglandin D2 receptor 2; prostaglandin D2 receptor 2; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD_antigen: CD294

products gene name :

GPR44

products gene name syn :

CRTH2; PTGDR2

other gene names :

PTGDR2; PTGDR2; DP2; DL1R; CD294; CRTH2; GPR44; CRTH2; DL1R; GPR44

uniprot entry name :

PD2R2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Gorilla, Human

sequence length :

395

specificity :

Residues 329-348 [DDSELGGAGSSRRRRTSSTA] of the CRTH2 (GPR44) protein. This sequence is near the C terminus.

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (10 ug/ml), WB (1:500 - 1:1000)

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human GPR44 / CRTH2. Percent identity by BLAST analysis: Human, Gorilla (100%); Pig (85%); Elephant (80%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: GPR44 / CRTH2 antibody was raised against synthetic peptide from human GPR44 / CRTH2. Percent identity by BLAST analysis: Human, Gorilla (100%); Pig (85%); Elephant (80%). Antigen Modification: aa329-348

products categories :

Family: GPCR. Subfamily: Prostanoid

products description :

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.

ncbi gi num :

153791424

ncbi acc num :

NP_004769.2

ncbi gb acc num :

NM_004778.2

uniprot acc num :

Q9Y5Y4

ncbi mol weight :

43,268 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Eicosanoid Ligand-binding Receptors Pathway (106370); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Prostanoid Ligand Receptors Pathway (106371)

ncbi summary :

This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

uniprot summary :

GPR44: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q12-q13.3. Cellular Component: neuron projection; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide binding; prostaglandin F receptor activity; prostaglandin J receptor activity; prostaglandin D receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; immune response; G-protein signaling, adenylate cyclase inhibiting pathway; chemotaxis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage