Rabbit Polyclonal to Human LPAR2 / EDG4 | MyBioSource MBS244899 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human LPAR2 / EDG4

catalog :

MBS244899

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS244899

products type :

Antibody

products full name :

Rabbit Polyclonal to Human LPAR2 / EDG4

products short name :

LPAR2 / EDG4

products name syn :

Anti-LPAR2 / EDG4 Antibody (Cytoplasmic Domain) IHC-plus; LPAR2; EDG4; LPA-2; LPA receptor 2; LPA receptor EDG4; LPA2; EDG-4; Human LPAR2; EDG4

other names :

lysophosphatidic acid receptor 2; Lysophosphatidic acid receptor 2; lysophosphatidic acid receptor 2; LPA receptor 2; LPA receptor EDG4; G protein-coupled receptor; lysophosphatidic acid receptor EDG4; lysophosphatidic acid receptor Edg-4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4; lysophosphatidic acid receptor 2; Lysophosphatidic acid receptor Edg-4

products gene name :

LPAR2

products gene name syn :

EDG4

other gene names :

LPAR2; LPAR2; EDG4; LPA2; EDG-4; LPA-2; EDG4; LPA2; LPA receptor 2; LPA-2

uniprot entry name :

LPAR2_HUMAN

clonality :

Polyclonal

host :

Rabbit

sequence length :

351

specificity :

Human LPAR2 / EDG4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)

app notes :

ICC, IHC-P (10 - 20 ug/ml)

other info1 :

Target Species: Human. Immunogen Description: Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human LPAR2 / EDG4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Panda, Bovine, Dog, Bat, Horse, Pig (100%); Mouse, Elephant (94%); Rat (89%); Rabbit (83%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: LPAR2 / EDG4 antibody was raised against synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human LPAR2 / EDG4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Panda, Bovine, Dog, Bat, Horse, Pig (100%); Mouse, Elephant (94%); Rat (89%); Rabbit (83%). Antigen Modification: Cytoplasmic Domain

products categories :

Family: GPCR. Subfamily: Lysophospholipid/Lysosphingolipid

products description :

Edg4 is a Lysophospholipid/Lysosphingolipid Receptor activated by phosphatidic acid (PA) and lysophosphatidic acid (LPA). It enhances the transcription of serum response element (SRE) reporter genes. In CD4(+) T cells, Edg4 may be involved in the control of interleukin-2 secretion.

ncbi gi num :

7305013

ncbi acc num :

NP_004711.2

ncbi gb acc num :

NM_004720.5

uniprot acc num :

Q9HBW0

ncbi mol weight :

39,084 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); LPA Receptor Mediated Events Pathway (137928); Lysosphingolipid And LPA Receptors Pathway (106376)

ncbi summary :

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

EDG4: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19p12. Cellular Component: cell surface; endocytic vesicle; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; protein binding; lipid binding; PDZ domain binding. Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; activation of MAPK activity; phospholipase C activation; positive regulation of Rho protein signal transduction

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage