Goat Polyclonal to Human MAP1LC3A / LC3A | MyBioSource MBS244864 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human MAP1LC3A / LC3A

catalog :

MBS244864

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS244864

products type :

Antibody

products full name :

Goat Polyclonal to Human MAP1LC3A / LC3A

products short name :

MAP1LC3A / LC3A

products name syn :

Anti-MAP1LC3A / LC3A Antibody (aa97-106) IHC-plus; MAP1LC3A; ATG8E; LC3; LC3A; MAP1BLC3; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; MAP1ALC3; Human MAP1LC3A; LC3A

other names :

microtubule-associated proteins 1A/1B light chain 3A isoform a; Microtubule-associated proteins 1A/1B light chain 3A; microtubule-associated proteins 1A/1B light chain 3A; MAP1A/MAP1B LC3 A; MAP1A/1B light chain 3 A; MAP1A/MAP1B light chain 3 A; MAP1 light chain 3-like protein 1; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated protein 1 light chain 3 alpha; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha

products gene name :

MAP1LC3A

products gene name syn :

LC3A

other gene names :

MAP1LC3A; MAP1LC3A; LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1A/MAP1B LC3 A

uniprot entry name :

MLP3A_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Bovine, Xenopus, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rat. Predicted Reactivity: Bat, Dog, Horse, Chicken, Drosophila (at least 90% immunogen sequence identity)

sequence length :

121

specificity :

Human MAP1LC3A.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (3.75 - 7.5 ug/ml)

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-DIYEQEKDED from positions 97-106 of human MAP1LC3A (NP_115903.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Pig, Xenopus (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MAP1LC3A / LC3A antibody was raised against synthetic peptide C-DIYEQEKDED from positions 97-106 of human MAP1LC3A (NP_115903.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Pig, Xenopus (100%); Elephant, Panda, Dog, Bat, Horse, Opossum, Turkey, Chicken, Platypus, Lizard, Drosophila (90%); Catfish, Salmon, Stickleback, Pufferfish, Zebrafish, Slime mold, Trichomonas (80%). Antigen Modification: aa97-106

products description :

Microtubule-associated proteins MAP1A and MAP1B are composed of a heavy chain and multiple light chains, one of which is LC3. There are three human LC3 orthologs, MAP1LC3A (alpha), MPA1LC3B (beta) and MAP1lC3C, which exhibit different expression patterns. In addition to copurifying with brain microtubules LC3 alpha proteins have also been found on autophagosome membranes.

ncbi gi num :

14210522

ncbi acc num :

NP_115903.1

ncbi gb acc num :

NM_032514.3

uniprot acc num :

Q9H492

ncbi mol weight :

14,493 Da

ncbi pathways :

Senescence And Autophagy Pathway (198780)

ncbi summary :

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

uniprot summary :

LC3A: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Two isoforms of the human protein are produced by alternative splicing. Protein type: Autophagy; Ubiquitin-like modifier; Microtubule-binding; Vesicle. Chromosomal Location of Human Ortholog: 20q11.22. Cellular Component: microtubule; extrinsic to membrane; late endosome; autophagic vacuole; cytoplasmic vesicle; cytosol. Molecular Function: protein binding; phosphatidylethanolamine binding; microtubule binding; GABA receptor binding; phospholipid binding. Biological Process: mitochondrion degradation; autophagic vacuole formation; cellular response to nitrogen starvation

size1 :

0.05 mg

price1 :

495 USD