antibody

Rabbit Polyclonal (IgG) to Human CD40

MBS244648

0.25 mL

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunoprecipitation

Antibody

Rabbit Polyclonal (IgG) to Human CD40

CD40

Anti-CD40 Antibody (C-Terminus) IHC-plus; CD40; B-cell surface antigen CD40; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TNFRSF5; Human CD40

tumor necrosis factor receptor superfamily member 5 isoform 1; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule; CD40 molecule, TNF receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40

CD40

CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5

TNR5_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

277

Immunoaffinity Purified

10 mM PBS, pH 7.4, BSA, sodium azide.

Store at 2 degree C to 8 degree C degrees. Do not freeze.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

IHC-P (1:100), IP, WB

Target Species: Human. Immunogen Description: A synthetic peptide derived from C-terminal of human CD40.

Immunogen Type: Synthetic peptide. Immunogen: CD40 antibody was raised against a synthetic peptide derived from C-terminal of human CD40. Antigen Modification: C-Terminus

Family: TNF Receptor

CD40 is a member of the TNF-receptor superfamily. It has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.

4507581

NP_001241.1

NM_001250.5

P25942

22,259 Da

Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); CD40/CD40L Signaling Pathway (138061); Cell Adhesion Molecules (CAMs) Pathway (83069)

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 20q12-q13.2. Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; receptor activity; antigen binding. Biological Process: B cell proliferation; platelet activation; positive regulation of isotype switching to IgG isotypes; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion. Disease: Immunodeficiency With Hyper-igm, Type 3

0.25 mL

495 USD