antibody

Rabbit Polyclonal to Human CCR7

MBS244613

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Rabbit Polyclonal to Human CCR7

CCR7

Anti-CCR7 Antibody (N-Terminus) IHC-plus; CCR7; BLR2; Chemokine (C-C) receptor 7; CD197; C-C CKR-7; CMKBR7; CC chemokine receptor 7; CCR-7; CD197 antigen; CDw197; EBI1; EVI1; MIP-3 beta receptor; C-c chemokine receptor 7; C-C chemokine receptor type 7; CC-CKR-7; Chemokine c-c motif receptor 7; Human CCR7

C-C chemokine receptor type 7; C-C chemokine receptor type 7; C-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitt's lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; chemokine (C-C motif) receptor 7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197

CCR7

CCR7; CCR7; BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; CMKBR7; EBI1; EVI1; C-C CKR-7; CC-CKR-7; CCR-7; EBI1; EBV-induced G-protein coupled receptor 1

CCR7_HUMAN

Polyclonal

Rabbit

Human

378

Human CCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin)

IHC-P (5 - 10 ug/ml)

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human CCR7. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Horse, Rabbit, Pig (100%).

Immunogen Type: Synthetic peptide. Immunogen: CCR7 antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human CCR7. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Horse, Rabbit, Pig (100%); Mouse, Rat, Hamster, Dog, Bat (94%). Antigen Modification: N-Terminus

Family: GPCR. Subfamily: Chemokine

CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7.

4502641

NP_001829.1

NM_001838.3

P32248

42,874 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q12-q21.2. Cellular Component: cell surface; integral to membrane; plasma membrane; intracellular; external side of plasma membrane. Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity. Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; inflammatory response; positive regulation of cell-matrix adhesion; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of pseudopodium formation; myeloid dendritic cell chemotaxis; positive regulation of actin filament polymerization; regulation of interferon-gamma production; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response

0.05 mg

495 USD