Goat Polyclonal to Human DICER1 / Dicer | MyBioSource MBS244505 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human DICER1 / Dicer

catalog :

MBS244505

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS244505

products type :

Antibody

products full name :

Goat Polyclonal to Human DICER1 / Dicer

products short name :

DICER1 / Dicer

products name syn :

Anti-DICER1 / Dicer Antibody (aa1389-1406) IHC-plus; DCR1; Dicer; Dicer 1; ribonuclease type III; Endoribonuclease Dicer; HERNA; Helicase-moi; MNG1; Helicase with RNase motif; Dicer1; Dcr-1 homolog; Helicase MOI; K12H4.8-LIKE; KIAA0928; Human DICER1; Dicer

other names :

endoribonuclease Dicer isoform 1; Endoribonuclease Dicer; endoribonuclease Dicer; helicase MOI; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Helicase with RNase motif; Helicase MOI

products gene name :

DICER1

other gene names :

DICER1; DICER1; DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE; DICER; HERNA; KIAA0928; Helicase MOI

uniprot entry name :

DICER_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Gorilla, Horse, Human, Monkey. Predicted Reactivity: Bovine, Dog, Rabbit (at least 90% immunogen sequence identity)

sequence length :

1922

specificity :

Human DICER1 / Dicer. Reported variants represent identical protein: NP_085124.2, NP_803187.1.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (3.75 - 7.5 ug/ml)

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide QDKSNTDKWEKDEMTKDC from an internal region of human DICER1 / Dicer (NP_085124.2; NP_803187.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Horse (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: DICER1 / Dicer antibody was raised against synthetic peptide QDKSNTDKWEKDEMTKDC from an internal region of human DICER1 / Dicer (NP_085124.2; NP_803187.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Horse (100%); Dog, Bovine, Rabbit, Opossum (94%); Mouse, Rat, Hamster, Bat (89%); Turkey, Chicken, Platypus (83%). Antigen Modification: aa1389-1406

ncbi gi num :

29294649

ncbi acc num :

NP_085124.2

ncbi gb acc num :

NM_030621.4

uniprot acc num :

Q9UPY3

ncbi mol weight :

92,726 Da

ncbi pathways :

Gene Expression Pathway (105937); MicroRNA (miRNA) Biogenesis Pathway (106335); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); Regulatory RNA Pathways (106334); Small Interfering RNA (siRNA) Biogenesis Pathway (576277); MRNA Processing Pathway (198843)

ncbi summary :

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

uniprot summary :

DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. Protein type: Cell development/differentiation; EC 3.1.26.3; Helicase; Ribonuclease; RNA-binding; RNA processing. Chromosomal Location of Human Ortholog: 14q32.13. Cellular Component: growth cone; axon; dendrite; cytoplasm; ER-Golgi intermediate compartment; nucleus; cytosol. Molecular Function: endoribonuclease activity; protein binding; ribonuclease III activity; miRNA binding; metal ion binding; double-stranded RNA binding; deoxyribonuclease I activity; helicase activity; ATP binding. Biological Process: zygote asymmetric cell division; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; DNA fragmentation during apoptosis; angiogenesis; defense response to virus; regulation of viral genome replication; positive regulation of myelination; spleen development; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; inner ear receptor cell development; multicellular organism growth; RNA interference, targeting of mRNA for destruction; mRNA stabilization; stem cell maintenance; RNA interference, conversion of ds siRNA to ss siRNA; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; cartilage development; gene expression; nerve development; cerebral cortex development; reproductive structure development; RNA interference, production of siRNA; neurite morphogenesis; myoblast cell differentiation involved in skeletal muscle regeneration; lung development. Disease: Pleuropulmonary Blastoma; Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Rhabdomyosarcoma, Embryonal, 2

size1 :

0.05 mg

price1 :

495 USD