Rabbit Polyclonal to Human LHCGR / LHR / LH Receptor | MyBioSource MBS244081 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human LHCGR / LHR / LH Receptor

catalog :

MBS244081

quantity :

0.05 mg

price :

530 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat, dog

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-LHCGR / LHR / LH Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

image 2 :

Anti-LHCGR / LHR / LH Receptor antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

image 3 :

Anti-hCG receptor antibody IHC of human ovary, corpus luteum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

product information

catalog number :

MBS244081

products type :

Antibody

products full name :

Rabbit Polyclonal to Human LHCGR / LHR / LH Receptor

products short name :

[LHCGR / LHR / LH Receptor]

products name syn :

[Anti-LHCGR / LHR / LH Receptor Antibody (C-Terminus) IHC-plus; LHCGR; HCG receptor; HHG; LCGR; LH/CGR; LHR; LH receptor; LHRHR; Lutropin receptor; LGR2; LH/CG-R; LSH-R; ULG5; Luteinizing hormone receptor; Human LHCGR; LHR; LH Receptor]

other names :

[lutropin-choriogonadotropic hormone receptor; Lutropin-choriogonadotropic hormone receptor; lutropin-choriogonadotropic hormone receptor; hypergonadotropic hypogonadism; lutropin/choriogonadotropin receptor; luteinizing hormone/choriogonadotropin receptor; Luteinizing hormone receptor; LHR; LSH-R]

products gene name :

[LHCGR]

other gene names :

[LHCGR; LHCGR; HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R; LCGR; LGR2; LHRHR; LH/CG-R; LHR; LSH-R]

uniprot entry name :

LSHR_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Reactivity: Human. Predicted Reactivity: Monkey, Rat, Dog

sequence length :

699

specificity :

Human hCG receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Upon arrival: Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (5 ug/ml)

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Target Species: Human. Target: LHCGR/LHR/LH Receptor. Immunogen Description: Synthetic 19 amino acid peptide from C-terminus of human hCG receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rat, Dog, Panda (95%); Bovine, Bat, Rabbit, Horse (89%); Ferret (84%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: LHCGR / LHR / LH Receptor antibody was raised against synthetic 19 amino acid peptide from C-terminus of human hCG receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rat, Dog, Panda (95%); Bovine, Bat, Rabbit, Horse (89%); Ferret (84%). Antigen Modification: C-Terminus

products categories :

Family: GPCR. Subfamily: Glycoprotein hormone

products description :

LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed.

ncbi gi num :

106067657

ncbi acc num :

NP_000224.2

ncbi gb acc num :

NM_000233.3

uniprot acc num :

P22888

ncbi pathways :

Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

uniprot summary :

LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: integral to plasma membrane; plasma membrane; endosome. Molecular Function: lutropin-choriogonadotropic hormone receptor activity. Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; male gonad development; adenylate cyclase activation; male genitalia development; positive regulation of inositol trisphosphate biosynthetic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); luteinizing hormone signaling pathway; cognition. Disease: Precocious Puberty, Male-limited; Leydig Cell Hypoplasia, Type I

size1 :

0.05 mg

price1 :

530 USD

more info or order :

MyBioSource product webpage