antibody

Rabbit Polyclonal to Human T1R3 / TAS1R3

MBS244011

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, chimpanzee

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human T1R3 / TAS1R3

T1R3 / TAS1R3

Anti-T1R3 / TAS1R3 Antibody (N-Terminus) IHC-plus; TAS1R3; Taste receptor type 1 member 3; TR3; Sweet taste receptor T1R3; T1R3; Human T1R3; TAS1R3

taste receptor type 1 member 3; Taste receptor type 1 member 3; taste receptor type 1 member 3; sweet taste receptor T1R3; taste receptor, type 1, member 3; Sweet taste receptor T1R3

T1R3

TAS1R3

TAS1R3; TAS1R3; T1R3; T1R3; TR3

TS1R3_HUMAN

Polyclonal

Rabbit

Chimpanzee, Gorilla, Human

852

Human TAS1R3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (10 - 20 ug/ml), WB

Target Species: Human. Immunogen Description: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon (100%); Orangutan (89%).

Immunogen Type: Synthetic peptide. Immunogen: T1R3 / TAS1R3 antibody was raised against synthetic 19 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon (100%); Orangutan (89%). Antigen Modification: N-Terminus

Family: GPCR. Subfamily: Taste

TAS1R3 is a Taste Receptor. TAS1R3 combines with TAS1R1 to function as an L-amino-acid receptor, and is only activated by these sweet amino acids.

91206396

NP_689414.1

NM_152228.1

Q7RTX0

93,386 Da

Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); GPCR Ligand Binding Pathway (161020); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356); Taste Transduction Pathway (83088)

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]

TAS1R3: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 1p36.33. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein heterodimerization activity; sweet taste receptor activity; taste receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; sensory perception of sweet taste; detection of chemical stimulus involved in sensory perception of sweet taste

0.05 mg

495 USD