antibody

Rabbit Polyclonal (IgG) to Human EDNRA / Endothelin A Receptor

MBS243959

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal (IgG) to Human EDNRA / Endothelin A Receptor

EDNRA / Endothelin A Receptor

Anti-EDNRA / Endothelin A Receptor Antibody (aa378-427) IHC-plus; EDNRA; Endothelin receptor subtype A; Et-a-r; ETRA; Endothelin A receptor; Endothelin eta receptor; Endothelin type a receptor; Endothelin-1 receptor; ETAR; Endothelin receptor type A; HET-AR; Et-a receptor; ETA; ETA-R; Human EDNRA; Endothelin A Receptor

endothelin-1 receptor isoform a; Endothelin-1 receptor; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor; endothelin receptor type A; Endothelin A receptor; ET-A; ETA-R; hET-AR

EDNRA

EDNRA; EDNRA; ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR; ETA; ETRA; ET-A; ETA-R; hET-AR

EDNRA_HUMAN

Polyclonal

IgG

EDNRA/Endothelin A Receptor antibody was produced in Rabbit

Human, Mouse

427

EDNRA Antibody detects endogenous levels of total EDNRA protein.

Immunoaffinity Purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

ELISA (1:1000), IF (1:100 - 1:500), IHC-P (2.5 ug/ml), WB (1:500 - 1:1000)

Target Species: Endothelin receptor type A (EDNRA). Immunogen Description: Synthetic peptide from human EDNRA (aa378-427). Family/Subfamily: GPCR/ Endothelin

Immunogen: EDNRA / Endothelin A Receptor antibody was raised against synthetic peptide from human EDNRA (aa378-427). Antigen Modification: aa378-427

Family: GPCR. Subfamily: Endothelin

The ETA receptor is an Endothelin Receptor that mediates the effects of endothelin-1, a mitogen with potent contractile properties. In the human fetal olfactory epithelium cell line FNC-B4, the ETA receptor increases the secretion of gonadotropin-releasing hormone. Increased ETA concentration may be correlated with smooth muscle hypertrophy observed in patients suffering from bladder-outlet obstruction.

4503465

NP_001948.1

NM_001957.3

P25101

23,803 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); EGFR-dependent Endothelin Signaling Events Pathway (138037); Endothelin Pathway (672453); Endothelins Pathway (137958); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548)

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 ET2 ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q31.22. Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft. Molecular Function: endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity. Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; response to morphine; smooth muscle cell proliferation; response to lipopolysaccharide; glucose transport; signal transduction; sensory perception of pain; enteric nervous system development; regulation of epithelial cell proliferation; Rho protein signal transduction; histamine secretion; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; protein kinase C activation; positive regulation of cell proliferation; artery smooth muscle contraction; penile erection; aging; vasoconstriction; in utero embryonic development; adenylate cyclase activation; glomerular filtration; respiratory gaseous exchange; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; cell proliferation; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; positive regulation of inflammatory response. Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1

0.05 mg

495 USD