Rabbit Polyclonal to Human FFAR1 / GPR40 | MyBioSource MBS243557 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human FFAR1 / GPR40

catalog :

MBS243557

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS243557

products type :

Antibody

products full name :

Rabbit Polyclonal to Human FFAR1 / GPR40

products short name :

FFAR1 / GPR40

products name syn :

Anti-FFAR1 / GPR40 Antibody (C-Terminus) IHC-plus; FFAR1; FFAR; FFA1R; G protein-coupled receptor 40; GPCR40; GPR40; Free fatty acid receptor; Free fatty acid receptor 1; G-protein coupled receptor 40; Human FFAR1; GPR40

other names :

free fatty acid receptor 1; Free fatty acid receptor 1; free fatty acid receptor 1; G protein-coupled receptor 40; G-protein coupled receptor 40; free fatty acid receptor 1; G-protein coupled receptor 40

products gene name :

FFAR1

products gene name syn :

GPR40

other gene names :

FFAR1; FFAR1; FFA1R; GPR40; GPCR40; GPR40

uniprot entry name :

FFAR1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gorilla, Human, Monkey

sequence length :

300

specificity :

Human GPR40. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (9 - 18 ug/ml), WB

other info1 :

Target Species: Human. Immunogen Description: Synthetic 18 amino acid peptide from C-terminus of human GPR40. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Rabbit (89%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: FFAR1 / GPR40 antibody was raised against synthetic 18 amino acid peptide from C-terminus of human GPR40. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Rabbit (89%). Antigen Modification: C-Terminus

products categories :

Family: GPCR. Subfamily: Carboxylic Acid

products description :

GPR40 is classified as a Carboxylic Acid GPCR that may be associated with glucose and insulin secretion to regulate pancreatic islet function. Additional roles in neurological functions have also been speculated.

ncbi gi num :

4885327

ncbi acc num :

NP_005294.1

ncbi gb acc num :

NM_005303.2

uniprot acc num :

O14842

ncbi mol weight :

31,457 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Fatty Acids Bound To GPR40 (FFAR1) Regulate Insulin Secretion Pathway (119537); Free Fatty Acid Receptors Pathway (161023); Free Fatty Acids Regulate Insulin Secretion Pathway (119536); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]

uniprot summary :

FFAR1: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; lipid binding; bioactive lipid receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion; energy reserve metabolic process; glucose homeostasis; positive regulation of calcium ion transport; regulation of insulin secretion; positive regulation of GTPase activity

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage