Goat Polyclonal to Human APH1A / APH-1 | MyBioSource MBS243196 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human APH1A / APH-1

catalog :

MBS243196

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS243196

products type :

Antibody

products full name :

Goat Polyclonal to Human APH1A / APH-1

products short name :

APH1A / APH-1

products name syn :

Anti-APH1A / APH-1 Antibody (Internal) IHC-plus; APH1A; Aph-1alpha; APH-1; CGI-78; PSF; APH-1A; Gamma-secretase subunit APH-1A; Human APH1A; APH-1

other names :

gamma-secretase subunit APH-1A isoform 2; Gamma-secretase subunit APH-1A; gamma-secretase subunit APH-1A; aph-1alpha; presenilin-stabilization factor; anterior pharynx defective 1 homolog A; APH1A gamma secretase subunit; Aph-1alpha; Presenilin-stabilization factor

products gene name :

APH1A

products gene name syn :

APH-1

other gene names :

APH1A; APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; APH-1a

uniprot entry name :

APH1A_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat. Predicted Reactivity: Bat (at least 90% immunogen sequence identity)

sequence length :

247

specificity :

Human APH1A. This antibody is expected to recognize isoform 1 (NP_001071096.1) and isoform 2 (NP_057106.2).

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:128000), IHC-P (5 ug/ml), WB (0.05 - 0.1 ug/ml)

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-HVTDRSDARLQYG from an internal region of human APH1A (NP_001071096.1; NP_057106.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: APH1A / APH-1 antibody was raised against synthetic peptide C-HVTDRSDARLQYG from an internal region of human APH1A (NP_001071096.1; NP_057106.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%); Elephant, Bat (92%); Opossum (85%). Antigen Modification: Internal

products categories :

Family: Protease Regulation

products description :

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).

ncbi gi num :

117606357

ncbi acc num :

NP_057106.2

ncbi gb acc num :

NM_016022.3

uniprot acc num :

Q96BI3

ncbi mol weight :

20,977 Da

ncbi pathways :

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Axon Guidance Pathway (105688); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Delta-Notch Signaling Pathway (198879); Developmental Biology Pathway (477129)

ncbi summary :

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]

uniprot summary :

APH1A: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 1p36.13-q31.3. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; membrane; integral to plasma membrane; endoplasmic reticulum; plasma membrane. Molecular Function: protein binding; endopeptidase activity. Biological Process: positive regulation of catalytic activity; axon guidance; amyloid precursor protein catabolic process; Notch signaling pathway; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; membrane protein ectodomain proteolysis; ephrin receptor signaling pathway; Notch receptor processing; protein processing; metanephros development

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage