antibody

Rabbit Polyclonal to Human ADAM8

MBS242896

0.05 mL

495 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human ADAM8

ADAM8

Anti-ADAM8 Antibody IHC-plus; ADAM metallopeptidase domain 8; Cell surface antigen MS2; ADAM 8; MS2; CD156; CD156a antigen; Human ADAM8

disintegrin and metalloproteinase domain-containing protein 8 isoform 1; Disintegrin and metalloproteinase domain-containing protein 8; disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8; ADAM metallopeptidase domain 8; Cell surface antigen MS2; CD_antigen: CD156a

ADAM8

ADAM8; ADAM8; MS2; CD156; CD156a; MS2; ADAM 8

ADAM8_HUMAN

Polyclonal

Rabbit

Human

824

Human ADAM8.

Immunoaffinity Purified

PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal

1 mg/ml

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (20 ug/ml), WB (1:500 - 1:3000)

Target Species: Human. Immunogen Description: Synthetic peptide containing a sequence corresponding to a region within amino acids 763 and 824 of Human CD156.

Immunogen Type: Synthetic peptide. Immunogen: ADAM8 antibody was raised against synthetic peptide containing a sequence corresponding to a region within amino acids 763 and 824 of Human CD156.

Family: Protease. Subfamily: Metallopeptidase M12B

ADAM8 is a Metallopeptidase M12B type protease.

256773264

NP_001100.3

NM_001109.4

P78325

80,262 Da

Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262)

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

ADAM8: Possible involvement in extravasation of leukocytes. Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-. Chromosomal Location of Human Ortholog: 10q26.3. Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane. Molecular Function: protein binding; protein self-association; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding. Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; positive regulation of protein kinase B signaling cascade; extracellular matrix disassembly; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis

0.05 mL

495 USD