catalog number :
MBS242631
products full name :
Goat Polyclonal to Human S100A9 / MRP14
products short name :
S100A9 / MRP14
products name syn :
Anti-S100A9 / MRP14 Antibody (Internal) IHC-plus; S100A9; 60B8AG; Calgranulin B; CFAG; CAGB; Calgranulin-B; Calprotectin L1H subunit; CGLB; L1Ag; MRP14; NIF; p14; Protein S100-A9; LIAG; MAC387; MRP-14; Human S100A9; MRP14
other names :
protein S100-A9; Protein S100-A9; protein S100-A9; MRP-14; calgranulin B; calgranulin-B; calprotectin L1H subunit; leukocyte L1 complex heavy chain; migration inhibitory factor-related protein 14; S100 calcium-binding protein A9 (calgranulin B); S100 calcium binding protein A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9
products gene name :
S100A9
products gene name syn :
MRP14
other gene names :
S100A9; S100A9; MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; CAGB; CFAG; MRP14; MRP-14; p14
uniprot entry name :
S10A9_HUMAN
reactivity :
Gibbon, Gorilla, Human. Predicted Reactivity: Monkey, Bovine, Hamster, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
specificity :
Human S100A9.
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:8000, 0.3 - 1 ug/ml), IHC-P (2.5 ug/ml), WB (0.3 - 1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-DTNADKQLSFEEF from an internal region of human S100A9 (NP_002956.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Hamster, Bovine, Rabbit, Horse, Pig (92%); Panda (85%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: S100A9 / MRP14 antibody was raised against synthetic peptide C-DTNADKQLSFEEF from an internal region of human S100A9 (NP_002956.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Hamster, Bovine, Rabbit, Horse, Pig (92%); Panda (85%). Antigen Modification: Internal
products description :
Also known as S100 calcium-binding protein A9 and migration inhibitory factor-related protein 14.
ncbi acc num :
NP_002956.1
ncbi gb acc num :
NM_002965.3
ncbi mol weight :
13,242 Da
ncbi summary :
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
uniprot summary :
S100A9: a calcium-binding regulatory protein of the S-100 family expressed by macrophages in acutely inflammated tissues and in chronic inflammations. May be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells. Interacts with CEACAM3 in a calcium-dependent manner. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular space; cytoskeleton; extracellular region; plasma membrane; nucleus; cytosol. Molecular Function: arachidonic acid binding; antioxidant activity; RAGE receptor binding; protein binding; signal transducer activity; zinc ion binding; microtubule binding; calcium ion binding. Biological Process: caspase activation; neutrophil chemotaxis; chemokine production; chronic inflammatory response; cytokine production; response to lipopolysaccharide; positive regulation of peptide secretion; signal transduction; positive regulation of cell growth; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; sequestering of zinc ion; response to ethanol; cell-cell signaling; response to zinc ion; defense response to bacterium; actin cytoskeleton reorganization; autophagy; innate immune response; regulation of integrin biosynthetic process; inflammatory response; defense response to fungus; regulation of cytoskeleton organization and biogenesis; positive regulation of inflammatory response