catalog number :
MBS242582
products full name :
Goat Polyclonal to Human G6PD
products short name :
G6PD
products name syn :
Anti-G6PD Antibody (aa308-320) IHC-plus; G6PD; G6PD1; Human G6PD
other names :
glucose-6-phosphate 1-dehydrogenase isoform a; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase
products gene name :
G6PD
other gene names :
G6PD; G6PD; G6PD1; G6PD
uniprot entry name :
G6PD_HUMAN
reactivity :
Chimpanzee, Xenopus, Gorilla, Human, Monkey. Predicted Reactivity: Gibbon, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Sheep, Zebrafish (at least 90% immunogen sequence identity)
specificity :
Human G6PD. This antibody is expected to recognise both reported isoforms (NP_000393.4 and NP_001035810.1).
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at -20 degree C. Minimize freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:32000), IHC-P (2.5 ug/ml), WB (1:32000, 0.03 - 0.1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-STNSDDVRDEKVK from an internal region of human G6PD (NP_000393.4 ; NP_001035810.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon, Monkey, Marmoset, Opossum, Platypus, Lizard, Xenopus, Pufferfish (100%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: G6PD antibody was raised against synthetic peptide C-STNSDDVRDEKVK from an internal region of human G6PD (NP_000393.4 ; NP_001035810.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon, Monkey, Marmoset, Opossum, Platypus, Lizard, Xenopus, Pufferfish (100%); Gibbon, Galago, Rat, Sheep, Hamster, Elephant, Panda, Bat, Dog, Bovine, Rabbit, Horse, Trout, Salmon, Stickleback, Zebrafish (92%); Mouse, Shrew, Cat, Medaka (85%). Antigen Modification: aa308-320
ncbi acc num :
NP_000393.4
ncbi gb acc num :
NM_000402.4
ncbi mol weight :
62,468 Da
ncbi pathways :
Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Central Carbon Metabolism In Cancer Pathway 1059538!!Central Carbon Metabolism In Cancer Pathway 1084231!!Disease Pathway 530764!!Glutathione Metabolism Pathway 82973!!Glutathione Metabolism Pathway 198824!!Glutathione Metabolism Pathway 343!!Glycogen Storage Diseases Pathway 1127581!!Metabolic Pathways 132956
ncbi summary :
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]