Rabbit Polyclonal to Human MMP14 | MyBioSource MBS242536 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human MMP14

catalog :

MBS242536

quantity :

0.25 mL

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS242536

products type :

Antibody

products full name :

Rabbit Polyclonal to Human MMP14

products short name :

MMP14

products name syn :

Anti-MMP14 Antibody (aa160-173) IHC-plus; MMP14; Membrane type-1 MMP; MT1-MMP; MT1MMP; MT-MMP; MT-MMP 1; Matrix metalloproteinase-14; MMP-14; MMP-X1; MTMMP1; Human MMP14

other names :

matrix metalloproteinase-14 preproprotein; Matrix metalloproteinase-14; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; matrix metallopeptidase 14 (membrane-inserted); MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP

products gene name :

MMP14

other gene names :

MMP14; MMP14; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP

uniprot entry name :

MMP14_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

582

purity :

Immunoaffinity Purified

form :

10 mM PBS, pH 7.4, BSA, sodium azide.

concentration :

0.2 mg/ml

storage stability :

Store at 2 degree C to 8 degree C degrees. Do not freeze.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: A synthetic peptide derived from aa 160-173 of human MMP-14 protein.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MMP14 antibody was raised against a synthetic peptide derived from aa 160-173 of human MMP-14 protein. Antigen Modification: aa160-173

products categories :

Family: Protease. Subfamily: Metallopeptidase M10A

products description :

MMP14 is a Metallopeptidase M10A type protease.

ncbi gi num :

4826834

ncbi acc num :

NP_004986.1

ncbi gb acc num :

NM_004995.3

uniprot acc num :

P50281

ncbi mol weight :

65,894 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502); HIF-2-alpha Transcription Factor Network Pathway (137956); Matrix Metalloproteinases Pathway (198900); Senescence And Autophagy Pathway (198780)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP14: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Up-regulated by NANOS1. Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. Belongs to the peptidase M10A family. Protein type: Protease; Membrane protein, integral; EC 3.4.24.80; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; focal adhesion; Golgi lumen; integral to plasma membrane; cytoplasm; melanosome; plasma membrane. Molecular Function: integrin binding; protein binding; protease activator activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; transcription factor activity. Biological Process: extracellular matrix organization and biogenesis; negative regulation of focal adhesion formation; male gonad development; tissue remodeling; embryonic cranial skeleton morphogenesis; proteolysis; positive regulation of cell growth; collagen catabolic process; extracellular matrix disassembly; branching morphogenesis of a tube; regulation of transcription, DNA-dependent; ovarian follicle development; response to mechanical stimulus; response to estrogen stimulus; endothelial cell proliferation; response to hypoxia; zymogen activation; response to oxidative stress; angiogenesis; astrocyte cell migration; endochondral ossification; positive regulation of cell migration; lung development. Disease: Winchester Syndrome

size1 :

0.25 mL

price1 :

495 USD