catalog number :
MBS242477
products full name :
Goat Polyclonal to Human MCAD / ACADM
products short name :
MCAD / ACADM
products name syn :
Anti-MCAD / ACADM Antibody (C-Terminus) IHC-plus; ACADM; ACAD1; MCAD; MCADH; Human MCAD; ACADM
other names :
medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain
products gene name :
MCAD
products gene name syn :
ACADM
other gene names :
ACADM; ACADM; MCAD; ACAD1; MCADH; MCAD
uniprot entry name :
ACADM_HUMAN
reactivity :
Chimpanzee, Gorilla, Human
specificity :
Human ACADM. This antibody is expected to recognise both reported isoforms.
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at -20 degree C. Minimize freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.01 - 0.1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-RLIVAREHIDKYKN from the C-terminus of human ACADM (NP_000007.1; NP_001120800.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Marmoset, Mouse, Rat, Horse, Opossum (86%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: MCAD / ACADM antibody was raised against synthetic peptide C-RLIVAREHIDKYKN from the C-terminus of human ACADM (NP_000007.1; NP_001120800.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Marmoset, Mouse, Rat, Horse, Opossum (86%). Antigen Modification: C-Terminus
products description :
ACADM encodes the medium-chain specific (C4 to C12 straight chain) Acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Clinical phenotypes are associated with ACADM hereditary deficiency.
ncbi acc num :
NP_000007.1
ncbi gb acc num :
NM_000016.5
ncbi mol weight :
47,020 Da
ncbi pathways :
Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway 106127!!Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway 106128!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Fatty Acid Beta Oxidation Pathway 198865!!Fatty Acid Degradation Pathway 82935!!Fatty Acid Degradation Pathway 296!!Fatty Acid Metabolism Pathway 868084!!Fatty Acid Metabolism Pathway 878045
ncbi summary :
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]