Rabbit Polyclonal (IgG) to Sheep YWHAH / 14-3-3 Eta | MyBioSource MBS242436 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Sheep YWHAH / 14-3-3 Eta

catalog :

MBS242436

quantity :

0.05 mL

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, cow

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242436

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Sheep YWHAH / 14-3-3 Eta

products short name :

YWHAH / 14-3-3 Eta

products name syn :

Anti-YWHAH / 14-3-3 Eta Antibody (N-Terminus) IHC-plus; YWHAH; 14-3-3 eta; 14-3-3 protein eta; Protein AS1; YWHA1; Sheep YWHAH; 14-3-3 Eta

other names :

14-3-3 protein eta; 14-3-3 protein eta; 14-3-3 protein eta; 14-3-3 eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta; Protein AS1

products gene name :

YWHAH

other gene names :

YWHAH; YWHAH; YWHA1; YWHA1

uniprot entry name :

1433F_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep. Predicted Reactivity: Mammal (at least 90% immunogen sequence identity)

sequence length :

246

specificity :

Recognizes 14-3-3 eta in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 eta is expressed principally in the brain although it is expressed at low levels in other tissues. The protein binds alpha-synuclein, forming part of Lewy bodies in Parkinson's disease and has been linked to early-onset schizophrenia. The eta isoform binds both gremlin 1, which is overexpressed in human cancers, and the DAL-1/Protein 4.1B tumor suppressor. Furthermore the glucocorticoid receptor is positively regulated by 14-3-3- eta. May not react with recombinant proteins that are not N-acetylated.

purity :

Unpurified serum

form :

Serum, 0.09% sodium azide.

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (1:250), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Sheep. Immunogen Description: Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 eta.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: YWHAH / 14-3-3 Eta antibody was raised against synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 eta. Antigen Modification: N-Terminus

ncbi gi num :

4507951

ncbi acc num :

NP_003396.1

ncbi gb acc num :

NM_003405.3

uniprot acc num :

Q04917

ncbi mol weight :

28,219 Da

ncbi pathways :

Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); Epstein-Barr Virus Infection Pathway (585562)

ncbi summary :

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

uniprot summary :

14-3-3 eta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Protein type: Nuclear receptor co-regulator; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 22q12.3. Cellular Component: cytoplasmic vesicle membrane; cytoplasm; plasma membrane; cytosol. Molecular Function: protein domain specific binding; insulin-like growth factor receptor binding; protein binding; enzyme binding; sodium channel regulator activity; protein heterodimerization activity; actin binding; glucocorticoid receptor binding. Biological Process: intracellular protein transport; substantia nigra development; apoptosis; regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; regulation of synaptic plasticity; glucocorticoid catabolic process; negative regulation of dendrite morphogenesis; regulation of sodium ion transport

size1 :

0.05 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage