antibody

Rabbit Polyclonal to Human CASP1 / Caspase 1

MBS242321

0.25 mL

495 USD

polyclonal

rabbit

nonconjugated

human, rat, dog, cow

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Rabbit Polyclonal to Human CASP1 / Caspase 1

CASP1 / Caspase 1

Anti-CASP1 / Caspase 1 Antibody IHC-plus; CASP1; Caspase-1; CASP-1; CASP1 nirs variant 1; Caspase 1; ICE; ICE-like protease; IL-1 beta-converting enzyme; IL-1BC; IL1BC; IL1BCE; p45; IL1B-convertase; Interleukin-1 beta convertase; Human CASP1; Caspase 1

caspase-1 isoform beta; Caspase-1; caspase-1; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10

CASP1

CASP1; CASP1; ICE; P45; IL1BC; IL1BC; IL1BCE; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme

CASP1_HUMAN

Polyclonal

Rabbit

Human. Predicted Reactivity: Mouse, Rat, Bovine, Dog, Pig (at least 90% immunogen sequence identity)

383

Immunoaffinity Purified

10 mM PBS, pH 7.4, BSA, sodium azide.

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC - Paraffin)

IHC-P (1:50). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: A synthetic peptide from the second quarter of human Caspase 1 protein.

Immunogen Type: Synthetic peptide. Immunogen: CASP1 / Caspase 1 antibody was raised against a synthetic peptide from the second quarter of human Caspase 1 protein.

Family: Protease. Subfamily: Cysteine C14

Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.

4502573

NP_001214.1

NM_001223.4

P29466

10,417 Da

Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Caspase Cascade In Apoptosis Pathway (137974); Cellular Roles Of Anthrax Toxin Pathway (138076); Cytokine Signaling In Immune System Pathway (366171); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Direct P53 Effectors Pathway (137939)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.22.36; Apoptosis. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: cytoplasm; extracellular region; cytosol. Molecular Function: protein binding; cysteine-type endopeptidase activity; endopeptidase activity; caspase activator activity. Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; membrane hyperpolarization; interleukin-1 beta production; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; mitochondrial depolarization; proteolysis; signal transduction; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of inflammatory response; response to hypoxia; innate immune response; regulation of autophagy

0.25 mL

495 USD