catalog number :
MBS242320
products full name :
Rabbit Polyclonal to Human IRS1 / IRS-1
products short name :
IRS1 / IRS-1
products name syn :
Anti-IRS1 / IRS-1 Antibody (aa1223-1242) IHC-plus; IRS1; IRS-1; HIRS-1; Insulin receptor substrate 1; Human IRS1; IRS-1
other names :
insulin receptor substrate 1; Insulin receptor substrate 1; insulin receptor substrate 1; IRS-1; insulin receptor substrate 1
products gene name :
IRS1
products gene name syn :
IRS-1
other gene names :
IRS1; IRS1; HIRS-1; IRS-1
uniprot entry name :
IRS1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Immunoaffinity Purified
form :
10 mM PBS, pH 7.4, BSA, sodium azide.
storage stability :
Store at 2 degree C to 8 degree C degrees. Do not freeze.
tested application :
Immunohistochemistry (IHC - Paraffin)
app notes :
IHC-P (15 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide corresponding to aa 1223-1242 of human IRS-1.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: IRS1 / IRS-1 antibody was raised against synthetic peptide corresponding to aa 1223-1242 of human IRS-1. Antigen Modification: aa1223-1242
ncbi acc num :
NP_005535.1
ncbi gb acc num :
NM_005544.2
ncbi mol weight :
131,591 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adaptive Immune System Pathway 366160!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198832!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Alpha6-Beta4 Integrin Signaling Pathway 198807
ncbi summary :
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]